Sympathetic Effect of Auricular Transcutaneous Vagus Nerve Stimulation on Healthy Subjects: A Crossover Controlled Clinical Trial Comparing Vagally Mediated and Active Control Stimulation Using Microneurography.
auricular branch of the vagus nerve
auricular transcutaneous vagus nerve stimulation
cardiac autonomic function
healthy subjects
muscle sympathetic nerve activity (MSNA)
Journal
Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006
Informations de publication
Date de publication:
2020
2020
Historique:
received:
28
08
2020
accepted:
16
11
2020
entrez:
21
12
2020
pubmed:
22
12
2020
medline:
22
12
2020
Statut:
epublish
Résumé
Auricular low-level transcutaneous vagus nerve stimulation (aLL-tVNS) has emerged as a promising technology for cardiac arrhythmia management but is still experimental. In this physiological study, we hypothesized that aLL-tVNS modulated the autonomic nervous balance through a reduction of sympathetic tone and an increase in heart rate variability (HRV). We investigated the muscle sympathetic nerve activity (MSNA) recorded by microneurography during vagally mediated aLL-tVNS and active control on healthy volunteers. In this crossover, double-blind controlled study, healthy men ( During apnea and compared to baseline, BF and MSNA activity increased ( Acute right cymba aLL-tVNS did not induce any overall effects neither on heart rate, HRV nor MSNA variables on healthy subjects when compared to active control. Interestingly, these findings questioned the role of active controls in medical device clinical trials that implied subjective endpoints.
Identifiants
pubmed: 33343394
doi: 10.3389/fphys.2020.599896
pmc: PMC7744823
doi:
Types de publication
Journal Article
Langues
eng
Pagination
599896Informations de copyright
Copyright © 2020 Gauthey, Morra, van de Borne, Deriaz, Maes and le Polain de Waroux.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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