The Expanding Cell Diversity of the Brain Vasculature.
astrocytes
blood brain barrier
endothelial cells
neurovascular unit
pericytes and vascular smooth muscle cells
perivascular fibroblasts
perivascular macrophages
single cell sequencing
Journal
Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006
Informations de publication
Date de publication:
2020
2020
Historique:
received:
31
08
2020
accepted:
10
11
2020
entrez:
21
12
2020
pubmed:
22
12
2020
medline:
22
12
2020
Statut:
epublish
Résumé
The cerebrovasculature is essential to brain health and is tasked with ensuring adequate delivery of oxygen and metabolic precursors to ensure normal neurologic function. This is coordinated through a dynamic, multi-directional cellular interplay between vascular, neuronal, and glial cells. Molecular exchanges across the blood-brain barrier or the close matching of regional blood flow with brain activation are not uniformly assigned to arteries, capillaries, and veins. Evidence has supported functional segmentation of the brain vasculature. This is achieved in part through morphologic or transcriptional heterogeneity of brain vascular cells-including endothelium, pericytes, and vascular smooth muscle. Advances with single cell genomic technologies have shown increasing cell complexity of the brain vasculature identifying previously unknown cell types and further subclassifying transcriptional diversity in cardinal vascular cell types. Cell-type specific molecular transitions or zonations have been identified. In this review, we summarize emerging evidence for the expanding vascular cell diversity in the brain and how this may provide a cellular basis for functional segmentation along the arterial-venous axis.
Identifiants
pubmed: 33343397
doi: 10.3389/fphys.2020.600767
pmc: PMC7744630
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
600767Subventions
Organisme : NCATS NIH HHS
ID : U2C TR002818
Pays : United States
Organisme : NINDS NIH HHS
ID : U54 NS065705
Pays : United States
Informations de copyright
Copyright © 2020 Ross, Kim, Allen, Crouch, Narsinh, Cooke, Abla, Nowakowski and Winkler.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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