MicroRNA-1291 Is Associated With Locoregional Metastases in Patients With Early-Stage Breast Cancer.
axillary lymph node dissection
breast cancer
metastasis
microRNAs
sentinel lymph node
Journal
Frontiers in genetics
ISSN: 1664-8021
Titre abrégé: Front Genet
Pays: Switzerland
ID NLM: 101560621
Informations de publication
Date de publication:
2020
2020
Historique:
received:
20
05
2020
accepted:
10
11
2020
entrez:
21
12
2020
pubmed:
22
12
2020
medline:
22
12
2020
Statut:
epublish
Résumé
Evidence that microRNAs (miRNAs) regulate the various steps of metastasis is increasing. Several studies have looked at the miRNA expression profile in primary breast tumors but few have compared primary tumor and sentinel lymph node (SLN) metastasis. We correlated the expression of miRNAs with the SLN status and the outcome of axillary lymph node dissection (ALND) in 60 patients with early breast cancer. We profiled the expression of miRNAs in paired breast tumor samples and SLNs using the NextSeq500 Illumina platform and key findings were validated by qPCR. MultiMiR Bioconductor and Reactome pathways analysis were performed to identify target genes and signaling pathways affected by altered expressed miRNAs. Our results show that nine miRNAs were differentially expressed in tumor tissues (
Identifiants
pubmed: 33343622
doi: 10.3389/fgene.2020.562114
pmc: PMC7738477
doi:
Types de publication
Journal Article
Langues
eng
Pagination
562114Informations de copyright
Copyright © 2020 Escuin, López-Vilaró, Bell, Mora, Moral, Pérez, Arqueros, Ramón y Cajal, Lerma and Barnadas.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Brain Res. 2020 Mar 1;1730:146646
pubmed: 31917138
Cancer Res. 2017 Oct 15;77(20):5445-5451
pubmed: 28807941
Nucleic Acids Res. 2014;42(17):e133
pubmed: 25063298
Cold Spring Harb Perspect Biol. 2012 Oct 01;4(10):
pubmed: 22935904
Mol Cell. 2008 Nov 21;32(4):519-28
pubmed: 19026782
PLoS One. 2013;8(2):e55910
pubmed: 23405235
Biochemistry (Mosc). 2013 Jun;78(6):638-50
pubmed: 23980890
Oncol Lett. 2019 Mar;17(3):3253-3260
pubmed: 30867757
Cells. 2020 Jan 23;9(2):
pubmed: 31979244
Theranostics. 2020 Jun 1;10(16):7193-7210
pubmed: 32641987
Int J Cancer. 2014 Jul 15;135(2):371-8
pubmed: 24921087
Mol Cancer. 2018 Feb 19;17(1):34
pubmed: 29455658
Oncol Rep. 2015 Nov;34(5):2665-73
pubmed: 26324125
Nucleic Acids Res. 2011 Jan;39(2):675-86
pubmed: 20846955
Cell. 2012 Dec 21;151(7):1542-56
pubmed: 23260141
Cancer Res. 2004 Aug 1;64(15):5245-50
pubmed: 15289330
Genome Biol. 2002 Jun 18;3(7):RESEARCH0034
pubmed: 12184808
Nat Rev Cancer. 2009 Apr;9(4):293-302
pubmed: 19262572
Mod Pathol. 2010 Dec;23(12):1567-76
pubmed: 20818337
Cancer Sci. 2013 Nov;104(11):1411-9
pubmed: 23889809
Oncotarget. 2016 Jul 19;7(29):45547-45561
pubmed: 27322206
PLoS One. 2017 Jan 25;12(1):e0170632
pubmed: 28122052
Carcinogenesis. 2014 Oct;35(10):2264-72
pubmed: 25115443
Breast Cancer Res Treat. 2011 Oct;129(3):767-76
pubmed: 21116709
J Clin Oncol. 2014 Nov 10;32(32):3600-6
pubmed: 25135994
Transl Res. 2011 Apr;157(4):216-25
pubmed: 21420032
Nucleic Acids Res. 2010 Apr;38(6):1767-71
pubmed: 20015970
Oncogene. 2014 Mar 6;33(10):1287-96
pubmed: 23474751
Mol Cancer Ther. 2014 Jul;13(7):1952-63
pubmed: 24817628
Clin Cancer Res. 2007 Aug 15;13(16):4807-16
pubmed: 17699859
Biomed Res Int. 2013;2013:976816
pubmed: 24195083
Breast Cancer Res Treat. 2013 May;139(1):87-93
pubmed: 23576079
Growth Factors. 2013 Feb;31(1):1-31
pubmed: 23256519
Transl Res. 2011 Apr;157(4):163-79
pubmed: 21420027
Mol Med Rep. 2017 Oct;16(4):4501-4510
pubmed: 28849001
Genome Biol. 2010;11(3):R25
pubmed: 20196867
J Mammary Gland Biol Neoplasia. 2012 Mar;17(1):23-32
pubmed: 22293951
RNA Biol. 2018;15(8):1133-1145
pubmed: 30223713
Nucleic Acids Res. 2020 Jan 8;48(D1):D498-D503
pubmed: 31691815
Ann Surg. 2010 Sep;252(3):426-32; discussion 432-3
pubmed: 20739842
Breast Cancer Res Treat. 2012 Jul;134(1):207-17
pubmed: 22294488
Bioinformatics. 2010 Jan 1;26(1):139-40
pubmed: 19910308
Semin Cell Dev Biol. 2018 Sep;81:78-87
pubmed: 29107170
Histopathology. 1991 Nov;19(5):403-10
pubmed: 1757079
Cancer Res. 1988 Oct 1;48(19):5565-9
pubmed: 3416309
J Clin Pathol. 2012 Mar;65(3):193-9
pubmed: 22090341
Tumour Biol. 2015 Jan;36(1):41-53
pubmed: 25420907
Genome Biol. 2007;8(10):R214
pubmed: 17922911
Drug Metab Dispos. 2015 Jul;43(7):1129-36
pubmed: 25934574
Genes Dev. 2009 Feb 1;23(3):265-77
pubmed: 19204114
Cancer Res. 2019 Apr 15;79(8):1719-1729
pubmed: 30952630
J Gastrointest Cancer. 2020 Mar;51(1):234-241
pubmed: 31028536