Detection of additional abnormalities or co-morbidities in women with suspected intrahepatic cholestasis of pregnancy.
Cholestasis
pregnancy
Journal
Obstetric medicine
ISSN: 1753-495X
Titre abrégé: Obstet Med
Pays: England
ID NLM: 101464191
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
25
06
2019
accepted:
19
07
2019
entrez:
21
12
2020
pubmed:
22
12
2020
medline:
22
12
2020
Statut:
ppublish
Résumé
Current guidelines recommend viral, autoimmune, coagulation and liver ultrasound testing in intrahepatic cholestasis of pregnancy to exclude alternative diagnoses. Electronic health records were searched for investigations and diagnoses in women with raised bile acid concentrations (>10 µmol/L) between January 2016 and December 2017 at two UK maternity units. Five hundred and thirty-one women had a raised bile acid concentration (median (IQR): 18 (13-32 µmol/L)) at a median gestation of 35.1 (IQR 31.8-37.0) weeks. Out of 531 women, 250 (47.1%) had full virology, autoimmune and ultrasound tests, and 348 (65.5%) had coagulation performed. Positive hepatitis B and C results were previously known. No new Epstein-Barr virus, cytomegalovirus or hepatitis A diagnoses were made. There were 11 positive autoimmune results, but no new diagnoses. No woman had an unexplained prolonged prothrombin time. No ultrasound liver ( Intrahepatic cholestasis of pregnancy investigations provided no new diagnoses that influenced clinical management during pregnancy.
Sections du résumé
BACKGROUND
BACKGROUND
Current guidelines recommend viral, autoimmune, coagulation and liver ultrasound testing in intrahepatic cholestasis of pregnancy to exclude alternative diagnoses.
METHODS
METHODS
Electronic health records were searched for investigations and diagnoses in women with raised bile acid concentrations (>10 µmol/L) between January 2016 and December 2017 at two UK maternity units.
RESULTS
RESULTS
Five hundred and thirty-one women had a raised bile acid concentration (median (IQR): 18 (13-32 µmol/L)) at a median gestation of 35.1 (IQR 31.8-37.0) weeks. Out of 531 women, 250 (47.1%) had full virology, autoimmune and ultrasound tests, and 348 (65.5%) had coagulation performed. Positive hepatitis B and C results were previously known. No new Epstein-Barr virus, cytomegalovirus or hepatitis A diagnoses were made. There were 11 positive autoimmune results, but no new diagnoses. No woman had an unexplained prolonged prothrombin time. No ultrasound liver (
CONCLUSION
CONCLUSIONS
Intrahepatic cholestasis of pregnancy investigations provided no new diagnoses that influenced clinical management during pregnancy.
Identifiants
pubmed: 33343695
doi: 10.1177/1753495X19868873
pii: 10.1177_1753495X19868873
pmc: PMC7726172
doi:
Types de publication
Journal Article
Langues
eng
Pagination
185-191Subventions
Organisme : Department of Health
ID : 12/164/16
Pays : United Kingdom
Organisme : Department of Health
ID : RP-2014-05-019
Pays : United Kingdom
Informations de copyright
© The Author(s) 2019.
Déclaration de conflit d'intérêts
Declaration of conflicting interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
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