Predicting and Managing Treatment Non-Response in Posttraumatic Stress Disorder.
PTSD
posttraumatic stress
predictor
psychotherapy
treatment resistant
Journal
Current treatment options in psychiatry
ISSN: 2196-3061
Titre abrégé: Curr Treat Options Psychiatry
Pays: Switzerland
ID NLM: 101626387
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
entrez:
21
12
2020
pubmed:
22
12
2020
medline:
22
12
2020
Statut:
ppublish
Résumé
This review aims to synthesize existing research regarding the definition of treatment resistance in posttraumatic stress disorder (PTSD), predictors of treatment non-response to first-line interventions, and emerging second-line PTSD treatment options into an accessible resource for the practicing clinician. The concept of treatment resistance in PTSD is currently poorly defined and operationalized. There are no well-established predictors of treatment non-response utilized in routine clinical care, but existing research identifies several potential candidate markers, including male gender, low social support, chronic and early life trauma exposure, comorbid psychiatric disorders, severe PTSD symptoms, and poor physical health. The most promising available treatment options for PTSD patients non-responsive to first-line psychotherapies and antidepressants include transcranial magnetic stimulation and ketamine infusion. Methylenedioxymethamphetamine-assisted psychotherapy also appears promising but is only available in a research context. These options require careful consideration of risks and benefits for a particular patient. More research is required to develop a robust, clinically-useful definition of treatment resistance in PTSD; identify reliable, readily assessable, and generalizable predictors of PTSD treatment non-response; and implement measurement and prediction in clinical settings to identify individuals unlikely to respond to first-line treatments and direct them to appropriate second-line treatments.
Identifiants
pubmed: 33344106
doi: 10.1007/s40501-020-00203-1
pmc: PMC7748158
mid: NIHMS1579000
doi:
Types de publication
Journal Article
Langues
eng
Pagination
70-87Subventions
Organisme : NIMH NIH HHS
ID : K23 MH114023
Pays : United States
Déclaration de conflit d'intérêts
Conflict of Interest The authors declare no conflict of interest.
Références
J Trauma Stress. 2018 Oct;31(5):753-763
pubmed: 30338573
Psychol Sci Public Interest. 2013 May;14(2):65-111
pubmed: 25722657
J Trauma Stress. 2002 Oct;15(5):359-67
pubmed: 12392223
J Affect Disord. 2018 Mar 15;229:506-514
pubmed: 29351885
Am J Psychiatry. 2004 Mar;161(3):515-24
pubmed: 14992978
Psychol Bull. 2006 Nov;132(6):959-92
pubmed: 17073529
Am J Public Health. 2009 Sep;99(9):1651-8
pubmed: 19608954
J Anxiety Disord. 2019 Apr;63:18-25
pubmed: 30785007
J Clin Psychiatry. 2008 Mar;69(3):400-5
pubmed: 18348595
J Consult Clin Psychol. 2016 Jan;84(1):43-56
pubmed: 26460570
Behav Ther. 2008 Mar;39(1):72-8
pubmed: 18328872
Behav Res Ther. 2009 Sep;47(9):737-43
pubmed: 19595295
J Trauma Stress. 2012 Oct;25(5):494-502
pubmed: 23047625
J Psychopharmacol. 2018 Dec;32(12):1295-1307
pubmed: 30371148
Am J Psychiatry. 2019 Nov 1;176(11):939-948
pubmed: 31230462
J Interpers Violence. 2021 Feb;36(3-4):1283-1307
pubmed: 29294985
JAMA Psychiatry. 2019 Nov 1;76(11):1159-1166
pubmed: 31433443
Psychol Trauma. 2016 May;8(3):356-64
pubmed: 26854354
JAMA Psychiatry. 2018 May 1;75(5):419-420
pubmed: 29562086
J Clin Psychiatry. 2014 Nov;75(11):e1299-305
pubmed: 25470095
J Clin Psychiatry. 2013 Jun;74(6):e541-50
pubmed: 23842024
Brain Stimul. 2014 Mar-Apr;7(2):151-7
pubmed: 24486424
Am J Psychiatry. 2005 Feb;162(2):214-27
pubmed: 15677582
Neuron. 2019 Mar 6;101(5):774-778
pubmed: 30844397
Clin Psychol Rev. 2019 Nov;73:101776
pubmed: 31707182
Am J Psychiatry. 2018 Dec 1;175(12):1205-1215
pubmed: 30153752
J Clin Psychiatry. 2007 Jan;68(1):37-46
pubmed: 17284128
J Psychiatr Res. 2017 Jun;89:125-135
pubmed: 28278422
Sci Transl Med. 2019 Apr 3;11(486):
pubmed: 30944165
Behav Res Ther. 2002 Apr;40(4):439-57
pubmed: 12002900
Lancet Psychiatry. 2018 Jun;5(6):486-497
pubmed: 29728331
Psychiatr Serv. 2014 Dec 1;65(12):1414-9
pubmed: 25082217
J Anxiety Disord. 2013 Aug;27(6):550-8
pubmed: 23422492
Psychotherapy (Chic). 2019 Sep;56(3):347-358
pubmed: 31282711
PLoS One. 2014 Jul 24;9(7):e101741
pubmed: 25058403
J Psychopharmacol. 2013 Jan;27(1):40-52
pubmed: 23118021
JAMA. 2003 Nov 19;290(19):2556-63
pubmed: 14625332
J Head Trauma Rehabil. 2009 Nov-Dec;24(6):430-8
pubmed: 19940676
Eur Arch Psychiatry Clin Neurosci. 2007 Feb;257(1):40-6
pubmed: 16915361
Clin Psychol Rev. 2016 Feb;43:128-41
pubmed: 26574151
Behav Res Ther. 2010 Jan;48(1):19-27
pubmed: 19766987
JAMA. 2015 Aug 4;314(5):489-500
pubmed: 26241600
Br J Psychiatry. 2012 Sep;201(3):186-92
pubmed: 22743844
Cochrane Database Syst Rev. 2006 Jan 25;(1):CD002795
pubmed: 16437445
J Clin Psychiatry. 2015 Aug;76(8):e1023-8
pubmed: 26335088
J Psychopharmacol. 2011 Apr;25(4):439-52
pubmed: 20643699
JAMA Psychiatry. 2019 Sep 1;76(9):904-913
pubmed: 31188399
Front Psychiatry. 2019 Sep 12;10:650
pubmed: 31572236
J Trauma Stress. 2017 Feb;30(1):45-53
pubmed: 28103415
Am J Psychiatry. 2010 Jun;167(6):640-7
pubmed: 20360318
J Clin Psychol. 2019 Mar;75(3):364-379
pubmed: 30485430
Br J Clin Psychol. 2017 Mar;56(1):69-83
pubmed: 27900778
Am J Psychiatry. 2011 Apr;168(4):356-64
pubmed: 21474597
J Trauma Stress. 2006 Oct;19(5):625-38
pubmed: 17075912
Clin Neurophysiol. 2009 Dec;120(12):2008-2039
pubmed: 19833552
J ECT. 2019 Mar;35(1):53-60
pubmed: 29952863
JAMA Psychiatry. 2015 Sep;72(9):875-81
pubmed: 26201054
Neuropsychology. 1998 Jan;12(1):125-33
pubmed: 9460740
J Anxiety Disord. 2014 Mar;28(2):237-40
pubmed: 24507630
J Affect Disord. 2018 Aug 1;235:414-420
pubmed: 29677606
J Consult Clin Psychol. 2001 Jun;69(3):541-51
pubmed: 11495183
Anxiety Stress Coping. 2016 Nov;29(6):630-43
pubmed: 26902309
Brain Stimul. 2012 Jan;5(1):38-43
pubmed: 22264669
Br J Psychiatry. 2016 Mar;208(3):252-9
pubmed: 26541687
Am J Psychiatry. 2015 Oct;172(10):950-66
pubmed: 26423481
J Anxiety Disord. 2016 Mar;38:55-61
pubmed: 26826984
Behav Sci (Basel). 2014 Dec 08;4(4):511-527
pubmed: 25494488
JAMA Psychiatry. 2019 Feb 1;76(2):117-126
pubmed: 30516797
Psychol Trauma. 2013 Jan 1;5(1):93-100
pubmed: 23869250
Am J Psychiatry. 2007 Mar;164(3):509-15
pubmed: 17329477
Prog Neuropsychopharmacol Biol Psychiatry. 2016 Oct 3;70:170-218
pubmed: 26854815
J Trauma Stress. 2019 Aug;32(4):577-585
pubmed: 31265187
Am J Psychiatry. 2019 Jun 1;176(6):422-424
pubmed: 31109197
J Clin Psychiatry. 2018 May/Jun;79(3):
pubmed: 29727073
Psychiatry Res. 2019 Mar;273:153-162
pubmed: 30641346
Depress Anxiety. 2016 Mar;33(3):247-55
pubmed: 26882293
Psychiatr Serv. 2009 Nov;60(11):1439-45
pubmed: 19880458
Eur J Psychotraumatol. 2017 Oct 10;8(1):1377028
pubmed: 29038682
Behav Ther. 2012 Dec;43(4):790-800
pubmed: 23046781
J Consult Clin Psychol. 2019 Nov;87(11):1019-1029
pubmed: 31556650
Psychol Trauma. 2017 Nov;9(6):647-654
pubmed: 28182456
J Trauma Stress. 2008 Apr;21(2):142-9
pubmed: 18404639
N Engl J Med. 2018 Feb 8;378(6):507-517
pubmed: 29414272
Gen Hosp Psychiatry. 2005 May-Jun;27(3):169-79
pubmed: 15882763
Biol Psychiatry. 2018 Sep 1;84(5):e37-e41
pubmed: 29752073
Behav Res Ther. 2003 Nov;41(11):1271-6
pubmed: 14527527
J Trauma Stress. 2017 Jun;30(3):288-295
pubmed: 28498555
Psychiatry. 2008 Summer;71(2):134-68
pubmed: 18573035
Can J Psychiatry. 2014 Sep;59(9):487-96
pubmed: 25565694
J Consult Clin Psychol. 2004 Jun;72(3):531-4
pubmed: 15279536
Psychol Trauma. 2016 Nov;8(6):720-727
pubmed: 27031079
J Nerv Ment Dis. 2003 Feb;191(2):93-9
pubmed: 12586962
J Behav Ther Exp Psychiatry. 2015 Sep;48:17-26
pubmed: 25677254
J Clin Psychiatry. 2015 Sep;76(9):1174-80
pubmed: 26455669
JAMA Psychiatry. 2014 Jun;71(6):681-8
pubmed: 24740528
Behav Res Ther. 2011 Apr;49(4):275-80
pubmed: 21333272
Psychol Med. 2018 Jan;48(1):95-103
pubmed: 29140225
J Pers Disord. 2002 Feb;16(1):30-40
pubmed: 11881159
J Neurotrauma. 2015 Jul 1;32(13):956-66
pubmed: 25350012
Behav Res Ther. 2000 Feb;38(2):191-202
pubmed: 10661003
Clin Psychol Rev. 2009 Dec;29(8):727-35
pubmed: 19744758