Behavioral response to fluoxetine in both female and male mice is modulated by dentate gyrus granule cell activity.
Antidepressant
Anxiety
Chronic stress
Dentate gyrus
Depression
Sex differences
Journal
Neurobiology of stress
ISSN: 2352-2895
Titre abrégé: Neurobiol Stress
Pays: United States
ID NLM: 101643409
Informations de publication
Date de publication:
Nov 2020
Nov 2020
Historique:
received:
21
08
2020
revised:
08
10
2020
accepted:
11
10
2020
entrez:
21
12
2020
pubmed:
22
12
2020
medline:
22
12
2020
Statut:
epublish
Résumé
Depression is a complex psychiatric disorder that is a major burden on society, with only ~33% of depressed patients attaining remission upon initial monotherapy with a selective serotonin reuptake inhibitor (SSRI). In preclinical studies using rodents, chronic stress paradigms, such as chronic corticosterone and social instability stress, are used to induce avoidance behaviors associated with negative affective states. Chronic fluoxetine (FLX; an SSRI) treatment reverses these chronic stress-induced behavioral changes in some, but not all mice, permitting stratification of mice into behavioral responders and non-responders to FLX. We previously reported that 5-HT
Identifiants
pubmed: 33344712
doi: 10.1016/j.ynstr.2020.100257
pii: S2352-2895(20)30047-3
pmc: PMC7739193
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100257Subventions
Organisme : NIMH NIH HHS
ID : R01 MH112861
Pays : United States
Informations de copyright
© 2020 The Authors.
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