Long-term effects of stress early in life on microRNA-30a and its network: Preventive effects of lurasidone and potential implications for depression vulnerability.
Axon guidance signaling
DNA methylation
Neurotrophin signaling
Prenatal stress
miR-30a
Journal
Neurobiology of stress
ISSN: 2352-2895
Titre abrégé: Neurobiol Stress
Pays: United States
ID NLM: 101643409
Informations de publication
Date de publication:
Nov 2020
Nov 2020
Historique:
received:
24
08
2020
revised:
05
11
2020
accepted:
16
11
2020
entrez:
21
12
2020
pubmed:
22
12
2020
medline:
22
12
2020
Statut:
epublish
Résumé
Exposure to early life stress can interfere with neurodevelopmental trajectories to increase the vulnerability for psychiatric disorders later in life. With this respect, epigenetic mechanisms play a key role for the long-lasting changes in brain functions that may elicit and sustain psychopathologic outcomes. Here, we investigated DNA methylation changes as possible epigenetic mechanism mediating the effect of prenatal stress (PNS), an experimental paradigm associated with behavioral and molecular alterations relevant for psychiatric disorders. We identified 138 genes as being differentially methylated in the prefrontal cortex (PFC) and in the hippocampus (HIP) of male and female adult rats exposed to PNS. Among these genes, miR-30a and Neurod1 emerged as potential players for the negative outcomes associated with PNS exposure. Indeed, in addition to showing consistent methylation differences in both brain regions and in both sexes, and interacting with each other, they are both involved in
Identifiants
pubmed: 33344724
doi: 10.1016/j.ynstr.2020.100271
pii: S2352-2895(20)30061-8
pmc: PMC7739180
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100271Subventions
Organisme : Medical Research Council
ID : G108/603
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N029488/1
Pays : United Kingdom
Informations de copyright
© 2020 The Authors.
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