White Matter Hyperintensities Quantification in Healthy Adults: A Systematic Review and Meta-Analysis.
image processing
segmentation
small vessel disease
white matter hyperintensities
Journal
Journal of magnetic resonance imaging : JMRI
ISSN: 1522-2586
Titre abrégé: J Magn Reson Imaging
Pays: United States
ID NLM: 9105850
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
revised:
02
12
2020
received:
24
09
2020
accepted:
03
12
2020
pubmed:
22
12
2020
medline:
20
5
2021
entrez:
21
12
2020
Statut:
ppublish
Résumé
Although white matter hyperintensities (WMH) volumetric assessment is now customary in research studies, inconsistent WMH measures among homogenous populations may prevent the clinical usability of this biomarker. To determine whether a point estimate and reference standard for WMH volume in the healthy aging population could be determined. Systematic review and meta-analysis. In all, 9716 adult subjects from 38 studies reporting WMH volume were retrieved following a systematic search on EMBASE. 1.0T, 1.5T, or 3.0T/fluid-attenuated inversion recovery (FLAIR) and/or proton density/T After a literature search, sample size, demographics, magnetic field strength, MRI sequences, level of automation in WMH assessment, study population, and WMH volume were extracted. The pooled WMH volume with 95% confidence interval (CI) was calculated using the random-effect model. The I Of the 38 studies analyzed, 17 reported WMH volume as the mean and standard deviation (SD) and were included in the meta-analysis. Mean and SD of age was 66.11 ± 10.92 years (percentage of men 50.45% ± 21.48%). Heterogeneity was very high (I The lack of standardization in the definition of WMH together with the high technical variability in assessment may explain a large component of the observed heterogeneity. Currently, volumes of WMH in healthy subjects are not comparable between studies and an estimate and reference interval could not be determined. 1 TECHNICAL EFFICACY STAGE: 1.
Sections du résumé
BACKGROUND
Although white matter hyperintensities (WMH) volumetric assessment is now customary in research studies, inconsistent WMH measures among homogenous populations may prevent the clinical usability of this biomarker.
PURPOSE
To determine whether a point estimate and reference standard for WMH volume in the healthy aging population could be determined.
STUDY TYPE
Systematic review and meta-analysis.
POPULATION
In all, 9716 adult subjects from 38 studies reporting WMH volume were retrieved following a systematic search on EMBASE.
FIELD STRENGTH/SEQUENCE
1.0T, 1.5T, or 3.0T/fluid-attenuated inversion recovery (FLAIR) and/or proton density/T
ASSESSMENT
After a literature search, sample size, demographics, magnetic field strength, MRI sequences, level of automation in WMH assessment, study population, and WMH volume were extracted.
STATISTICAL TESTS
The pooled WMH volume with 95% confidence interval (CI) was calculated using the random-effect model. The I
RESULTS
Of the 38 studies analyzed, 17 reported WMH volume as the mean and standard deviation (SD) and were included in the meta-analysis. Mean and SD of age was 66.11 ± 10.92 years (percentage of men 50.45% ± 21.48%). Heterogeneity was very high (I
DATA CONCLUSION
The lack of standardization in the definition of WMH together with the high technical variability in assessment may explain a large component of the observed heterogeneity. Currently, volumes of WMH in healthy subjects are not comparable between studies and an estimate and reference interval could not be determined.
LEVEL OF EVIDENCE
1 TECHNICAL EFFICACY STAGE: 1.
Types de publication
Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1732-1743Informations de copyright
© 2020 International Society for Magnetic Resonance in Medicine.
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