Tauroursodeoxycholic acid (TUDCA) is neuroprotective in a chronic mouse model of Parkinson's disease.
1-methyl-4-phenyl-1-2- 3-6-tetrahydropyridine (MPTP)
Parkinson’s disease
alpha synuclein
autophagy
dopamine transporter
dopaminergic neurons
lysosome-associated membrane protein 1 (LAMP-1)
tauroursodeoxycholic acid
tyrosine hydroxylase
Journal
Nutritional neuroscience
ISSN: 1476-8305
Titre abrégé: Nutr Neurosci
Pays: England
ID NLM: 100892202
Informations de publication
Date de publication:
Jul 2022
Jul 2022
Historique:
pubmed:
22
12
2020
medline:
22
6
2022
entrez:
21
12
2020
Statut:
ppublish
Résumé
Parkinson's disease (PD) is a progressive motor disease of unknown etiology. Although neuroprotective ability of endogenous bile acid, tauroursodeoxycholic acid (TUDCA), shown in various diseases, including an acute model of PD,the potential therapeutic role of TUDCA in progressive models of PD that exhibit all aspects of PD has not been elucidated. In the present study, mice were assigned to one of four treatment groups: (1) Probenecid (PROB); (2) TUDCA, (3) MPTP + PROB (MPTPp); and (3) TUDCA + MPTPp.
Identifiants
pubmed: 33345721
doi: 10.1080/1028415X.2020.1859729
doi:
Substances chimiques
Neuroprotective Agents
0
Taurochenodeoxycholic Acid
516-35-8
ursodoxicoltaurine
60EUX8MN5X
Dopamine
VTD58H1Z2X
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM