SlitC-PlexinA1 mediates iterative inhibition for orderly passage of spinal commissural axons through the floor plate.
axon guidance
chicken
commissural axons
developmental biology
midline crossing
mouse
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
21 12 2020
21 12 2020
Historique:
received:
17
09
2020
accepted:
18
12
2020
pubmed:
22
12
2020
medline:
19
3
2021
entrez:
21
12
2020
Statut:
epublish
Résumé
Spinal commissural axon navigation across the midline in the floor plate requires repulsive forces from local Slit repellents. The long-held view is that Slits push growth cones forward and prevent them from turning back once they became sensitized to these cues after midline crossing. We analyzed with fluorescent reporters Slits distribution and FP glia morphology. We observed clusters of Slit-N and Slit-C fragments decorating a complex architecture of glial basal process ramifications. We found that PC2 proprotein convertase activity contributes to this pattern of ligands. Next, we studied Slit-C acting via PlexinA1 receptor shared with another FP repellent, the Semaphorin3B, through generation of a mouse model baring PlexinA1
Identifiants
pubmed: 33345773
doi: 10.7554/eLife.63205
pii: 63205
pmc: PMC7775108
doi:
pii:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Video-Audio Media
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Agence Nationale de la Recherche
ID : ANR-11-IDEX-0007
Pays : International
Organisme : Fondation pour la Recherche Médicale
ID : Label team
Pays : International
Informations de copyright
© 2020, Ducuing et al.
Déclaration de conflit d'intérêts
HD, TG, AP, KK, MB, OT, CD, ST, VC No competing interests declared
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