The expression profile and role of non-coding RNAs in obesity.
Expression profile
Non-coding RNAs
Obesity
lncRNA
miRNA
Journal
European journal of pharmacology
ISSN: 1879-0712
Titre abrégé: Eur J Pharmacol
Pays: Netherlands
ID NLM: 1254354
Informations de publication
Date de publication:
05 Feb 2021
05 Feb 2021
Historique:
received:
23
10
2020
revised:
07
12
2020
accepted:
11
12
2020
pubmed:
22
12
2020
medline:
19
5
2021
entrez:
21
12
2020
Statut:
ppublish
Résumé
Latest years have experienced a dramatic upsurge in the knowledge about the function of non-coding transcripts in the determination of diverse human phenotypes including obesity. Several miRNAs and lncRNAs participate in the regulation of metabolic pathways leading to obesity. Several lncRNAs such as Mist, lincIRS2, lncRNA-p5549, H19, GAS5 and SNHG9 have been shown to be down-regulated in adipose tissues or other biological samples in the obese human or animal subjects. On the other hand, Meg3, Plnc1, Blnc1, AC092834.1, TINCR and PVT1 are among up-regulated lncRNAs in the obese subjects. Tens of miRNAs have differential expression between obese and non-obese subjects or between mature adipocytes and pre-adipocytes. Understanding the molecular mechanism of involvement of non-coding RNAs in the pathobiology of obesity would simplify design of therapeutic choices for protecting against obesity and its related comorbidities. We explain the available literature on the function of these transcripts in the pathobiology of obesity.
Identifiants
pubmed: 33345852
pii: S0014-2999(20)30914-6
doi: 10.1016/j.ejphar.2020.173809
pii:
doi:
Substances chimiques
MicroRNAs
0
RNA, Circular
0
RNA, Long Noncoding
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
173809Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.