Therapeutic blockade of CXCR2 rapidly clears inflammation in arthritis and atopic dermatitis models: demonstration with surrogate and humanized antibodies.
CXCR2
arthritis
atopic Dermatitis
inflammation
neutrophil
therapeutic antibody
Journal
mAbs
ISSN: 1942-0870
Titre abrégé: MAbs
Pays: United States
ID NLM: 101479829
Informations de publication
Date de publication:
Historique:
entrez:
21
12
2020
pubmed:
22
12
2020
medline:
8
10
2021
Statut:
ppublish
Résumé
Neutrophils are the most abundant effector cells of the innate immune system and represent the first line of defense against infection. However, in many common pathologies, including autoimmune diseases, excessive recruitment and activation of neutrophils can drive a chronic inflammatory response leading to unwanted tissue destruction. Several strategies have been investigated to tackle pathologic neutrophil biology, and thus provide a novel therapy for chronic inflammatory diseases. The chemokine receptor CXCR2 plays a crucial role in regulating neutrophil homeostasis and is a promising pharmaceutical target. In this study, we report the discovery and validation of a humanized anti-human CXCR2 monoclonal antibody. To enable
Identifiants
pubmed: 33347356
doi: 10.1080/19420862.2020.1856460
pmc: PMC7757791
doi:
Substances chimiques
Antibodies, Monoclonal, Humanized
0
CXCR2 protein, human
0
Receptors, Interleukin-8B
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Video-Audio Media
Langues
eng
Sous-ensembles de citation
IM
Pagination
1856460Références
Arthritis Rheum. 2010 Jul;62(7):1921-32
pubmed: 20506316
J Clin Invest. 2006 Mar;116(3):695-702
pubmed: 16485040
Biochem Biophys Res Commun. 2010 Jan 1;391(1):1080-6
pubmed: 20004647
J Pharmacol Exp Ther. 2009 Apr;329(1):123-9
pubmed: 19131582
Eur J Immunol. 2005 Oct;35(10):3064-73
pubmed: 16180250
Exp Biol Med (Maywood). 2014 May;239(5):509-18
pubmed: 24625439
Immunobiology. 2004;209(3):225-33
pubmed: 15518334
Science. 2002 Sep 6;297(5587):1689-92
pubmed: 12215644
Elife. 2019 Oct 21;8:
pubmed: 31631836
J Intern Med. 2001 Aug;250(2):91-104
pubmed: 11489059
Nat Immunol. 2018 Dec;19(12):1286-1298
pubmed: 30446754
Protein Sci. 2010 Feb;19(2):299-308
pubmed: 20014445
Immunity. 2012 Oct 19;37(4):747-58
pubmed: 23063331
Nat Immunol. 2008 Sep;9(9):988-98
pubmed: 18711436
J Dermatol. 1999 Nov;26(11):770-9
pubmed: 10635621
Clin Rev Allergy Immunol. 2011 Dec;41(3):298-310
pubmed: 21249468
Eur Cytokine Netw. 2006 Mar;17(1):42-8
pubmed: 16613762
J Allergy Clin Immunol. 2013 Aug;132(2):361-70
pubmed: 23777851
Cell Tissue Res. 2018 Mar;371(3):531-539
pubmed: 29383445
Front Pharmacol. 2016 Oct 25;7:391
pubmed: 27826243
Nat Biotechnol. 2006 Oct;24(10):1279-84
pubmed: 16980974
J Immunol. 2001 Aug 1;167(3):1601-8
pubmed: 11466382
Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W435-40
pubmed: 15215425
Arthritis Res. 2000;2(3):189-202
pubmed: 11094428
J Allergy Clin Immunol. 2017 Feb;139(2):562-571
pubmed: 27702671
J Leukoc Biol. 1999 Aug;66(2):286-92
pubmed: 10449169
Am J Pathol. 2008 Apr;172(4):940-50
pubmed: 18292234
Cell Death Differ. 2017 Oct;24(10):1821-1822
pubmed: 28753205
J Allergy Clin Immunol. 2009 Dec;124(6):1235-1244.e58
pubmed: 20004782
Clin Exp Allergy. 2019 Jan;49(1):130-132
pubmed: 30218547
Sci Rep. 2019 Feb 4;9(1):1351
pubmed: 30718650
MAbs. 2014;6(6):1425-38
pubmed: 25484064
Autoimmun Rev. 2011 Aug;10(10):577-81
pubmed: 21536152
J Immunol. 2018 Jan 1;200(1):130-138
pubmed: 29150565
J Immunol. 2009 Mar 1;182(5):3121-30
pubmed: 19234209
Nat Commun. 2015 Jun 25;6:7464
pubmed: 26108163
Nat Immunol. 2001 Feb;2(2):95-101
pubmed: 11175800
Immunity. 2010 Aug 27;33(2):266-78
pubmed: 20727790
Sci Transl Med. 2013 Jan 30;5(170):170ra16
pubmed: 23363980
Eur J Immunol. 2005 Sep;35(9):2573-82
pubmed: 16094689
Lancet. 2016 Mar 12;387(10023):1109-1122
pubmed: 26377142
J Invest Dermatol. 2000 Aug;115(2):234-44
pubmed: 10951241
Nat Med. 2009 Jul;15(7):766-73
pubmed: 19561618
Science. 1994 Jul 29;265(5172):682-4
pubmed: 8036519
Adv Wound Care (New Rochelle). 2013 Sep;2(7):379-388
pubmed: 24527354
Bioinformatics. 2004 Aug 4;20 Suppl 1:i379-85
pubmed: 15262823
J Allergy Clin Immunol. 2012 Dec;130(6):1335-43.e5
pubmed: 22920495
Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11736-41
pubmed: 16880407
J Exp Med. 2006 Apr 17;203(4):837-42
pubmed: 16567388
Arthritis Res. 2000;2(6):489-503
pubmed: 11056679
JCI Insight. 2017 Aug 3;2(15):
pubmed: 28768901
J Pharmacol Exp Ther. 2007 Aug;322(2):486-93
pubmed: 17496165
J Allergy Clin Immunol. 2013 Oct;132(4):789-801; quiz 788
pubmed: 24075190
J Invest Dermatol. 2018 Dec;138(12):2606-2616
pubmed: 29964034
J Immunol. 2016 Dec 1;197(11):4392-4402
pubmed: 27807194
Eur Respir J. 2010 Mar;35(3):564-70
pubmed: 19643947
Curr Opin Hematol. 2019 Jan;26(1):28-33
pubmed: 30407218
J Allergy Clin Immunol. 2011 May;127(5):1110-8
pubmed: 21388665
J Biol Chem. 1996 Dec 6;271(49):31202-9
pubmed: 8940121
J Immunol. 2016 Aug 15;197(4):1089-99
pubmed: 27412416