Decontaminating N95 respirators during the COVID-19 pandemic: simple and practical approaches to increase decontamination capacity, speed, safety and ease of use.


Journal

The Journal of hospital infection
ISSN: 1532-2939
Titre abrégé: J Hosp Infect
Pays: England
ID NLM: 8007166

Informations de publication

Date de publication:
Mar 2021
Historique:
received: 21 08 2020
revised: 14 12 2020
accepted: 14 12 2020
pubmed: 22 12 2020
medline: 3 3 2021
entrez: 21 12 2020
Statut: ppublish

Résumé

The COVID-19 pandemic has caused a severe shortage of personal protective equipment (PPE), especially N95 respirators. Efficient, effective and economically feasible methods for large-scale PPE decontamination are urgently needed. (1) to develop protocols for effectively decontaminating PPE using vaporized hydrogen peroxide (VHP); (2) to develop novel approaches that decrease set-up and take-down time while also increasing decontamination capacity; (3) to test decontamination efficiency for N95 respirators heavily contaminated by make-up or moisturizers. We converted a decommissioned Biosafety Level 3 laboratory into a facility that could be used to decontaminate N95 respirators. N95 respirators were hung on metal racks, stacked in piles, placed in paper bags or covered with make-up or moisturizer. A VHP® VICTORY™ unit from STERIS was used to inject VHP into the facility. Biological and chemical indicators were used to validate the decontamination process. N95 respirators individually hung on metal racks were successfully decontaminated using VHP. N95 respirators were also successfully decontaminated when placed in closed paper bags or if stacked in piles of up to six. Stacking reduced the time needed to arrange N95 respirators for decontamination by approximately two-thirds while almost tripling facility capacity. Make-up and moisturizer creams did not interfere with the decontamination process. Respirator stacking can reduce the hands-on time and increase decontamination capacity. When personalization is needed, respirators can be decontaminated in labelled paper bags. Make up or moisturizers do not appear to interfere with VHP decontamination.

Sections du résumé

BACKGROUND BACKGROUND
The COVID-19 pandemic has caused a severe shortage of personal protective equipment (PPE), especially N95 respirators. Efficient, effective and economically feasible methods for large-scale PPE decontamination are urgently needed.
AIMS OBJECTIVE
(1) to develop protocols for effectively decontaminating PPE using vaporized hydrogen peroxide (VHP); (2) to develop novel approaches that decrease set-up and take-down time while also increasing decontamination capacity; (3) to test decontamination efficiency for N95 respirators heavily contaminated by make-up or moisturizers.
METHODS METHODS
We converted a decommissioned Biosafety Level 3 laboratory into a facility that could be used to decontaminate N95 respirators. N95 respirators were hung on metal racks, stacked in piles, placed in paper bags or covered with make-up or moisturizer. A VHP® VICTORY™ unit from STERIS was used to inject VHP into the facility. Biological and chemical indicators were used to validate the decontamination process.
FINDINGS RESULTS
N95 respirators individually hung on metal racks were successfully decontaminated using VHP. N95 respirators were also successfully decontaminated when placed in closed paper bags or if stacked in piles of up to six. Stacking reduced the time needed to arrange N95 respirators for decontamination by approximately two-thirds while almost tripling facility capacity. Make-up and moisturizer creams did not interfere with the decontamination process.
CONCLUSIONS CONCLUSIONS
Respirator stacking can reduce the hands-on time and increase decontamination capacity. When personalization is needed, respirators can be decontaminated in labelled paper bags. Make up or moisturizers do not appear to interfere with VHP decontamination.

Identifiants

pubmed: 33347939
pii: S0195-6701(20)30570-3
doi: 10.1016/j.jhin.2020.12.006
pmc: PMC7748974
pii:
doi:

Substances chimiques

Hydrogen Peroxide BBX060AN9V

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

52-57

Commentaires et corrections

Type : UpdateOf

Informations de copyright

Copyright © 2020 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.

Auteurs

R Russo (R)

Center for Emerging Pathogens, New Jersey Medical School, Rutgers University, Newark, NJ, USA.

C Levine (C)

Center for Emerging Pathogens, New Jersey Medical School, Rutgers University, Newark, NJ, USA.

C Grady (C)

Center for Emerging Pathogens, New Jersey Medical School, Rutgers University, Newark, NJ, USA.

B Peixoto (B)

Center for Emerging Pathogens, New Jersey Medical School, Rutgers University, Newark, NJ, USA.

J McCormick-Ell (J)

Rutgers Environmental Health and Safety, Rutgers University, Newark, NJ, USA.

T Block (T)

Rutgers Environmental Health and Safety, Rutgers University, Newark, NJ, USA.

A Gresko (A)

Rutgers Environmental Health and Safety, Rutgers University, Newark, NJ, USA.

G Delmas (G)

Rutgers Environmental Health and Safety, Rutgers University, Newark, NJ, USA.

P Chitale (P)

Center for Emerging Pathogens, New Jersey Medical School, Rutgers University, Newark, NJ, USA.

A Frees (A)

Rutgers Environmental Health and Safety, Rutgers University, Newark, NJ, USA.

A Ruiz (A)

Rutgers Environmental Health and Safety, Rutgers University, Newark, NJ, USA.

D Alland (D)

Center for Emerging Pathogens, New Jersey Medical School, Rutgers University, Newark, NJ, USA. Electronic address: allandda@njms.rutgers.edu.

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Classifications MeSH