Clinical characteristics of bipolar disorders with postpartum depressive onset.
Journal
Progress in neuro-psychopharmacology & biological psychiatry
ISSN: 1878-4216
Titre abrégé: Prog Neuropsychopharmacol Biol Psychiatry
Pays: England
ID NLM: 8211617
Informations de publication
Date de publication:
20 04 2021
20 04 2021
Historique:
received:
18
08
2020
revised:
30
11
2020
accepted:
13
12
2020
pubmed:
22
12
2020
medline:
15
1
2022
entrez:
21
12
2020
Statut:
ppublish
Résumé
Postpartum period is associated with an increased risk of bipolar disorder diagnosis and relapse, mainly major depressive episode. Onset during this period might be associated with specific characteristics. To compare the socio-demographic and clinical characteristics of parous women presenting with bipolar disorder and an index depressive episode occurring during or outside the postpartum period. Using the multicenter cohort FACE-BD (FondaMental Academic Centers of Expertise for Bipolar Disorders), we considered all women who started their BD with a major depressive episode and have at least one child. We compared two groups depending on the onset: in or outside the postpartum period. Among the 759 women who started BD with a major depressive episode, 93 (12.2%) had a postpartum onset, and 666 (87.8%) had not. Women who started BD in the postpartum period with a major depressive episode have a more stable family life, more children, an older age at onset, more Bipolar 2 disorder, less history of suicide attempts, less depressive episodes and more mood stabilizer treatments as compared to those who started with a major depressive episode outside the postpartum period. The multivariable logistic regression showed that women with an onset in the postpartum period had significantly more children, less lifetime depressive episodes and a lower rate of history of suicide attempts as compared to women with an onset outside the postpartum period. Our results suggest that women starting their BD with postpartum depression have a more favorable course of BD, especially less history of suicide attempt and less lifetime depressive episodes.
Sections du résumé
BACKGROUND
Postpartum period is associated with an increased risk of bipolar disorder diagnosis and relapse, mainly major depressive episode. Onset during this period might be associated with specific characteristics.
AIM
To compare the socio-demographic and clinical characteristics of parous women presenting with bipolar disorder and an index depressive episode occurring during or outside the postpartum period.
METHODS
Using the multicenter cohort FACE-BD (FondaMental Academic Centers of Expertise for Bipolar Disorders), we considered all women who started their BD with a major depressive episode and have at least one child. We compared two groups depending on the onset: in or outside the postpartum period.
RESULTS
Among the 759 women who started BD with a major depressive episode, 93 (12.2%) had a postpartum onset, and 666 (87.8%) had not. Women who started BD in the postpartum period with a major depressive episode have a more stable family life, more children, an older age at onset, more Bipolar 2 disorder, less history of suicide attempts, less depressive episodes and more mood stabilizer treatments as compared to those who started with a major depressive episode outside the postpartum period. The multivariable logistic regression showed that women with an onset in the postpartum period had significantly more children, less lifetime depressive episodes and a lower rate of history of suicide attempts as compared to women with an onset outside the postpartum period.
DISCUSSION
Our results suggest that women starting their BD with postpartum depression have a more favorable course of BD, especially less history of suicide attempt and less lifetime depressive episodes.
Identifiants
pubmed: 33347983
pii: S0278-5846(20)30541-8
doi: 10.1016/j.pnpbp.2020.110225
pii:
doi:
Types de publication
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
110225Investigateurs
B Etain
(B)
C Henry
(C)
E Olié
(E)
M Leboyer
(M)
E Haffen
(E)
P M Llorca
(PM)
V Barteau
(V)
S Bensalem
(S)
O Godin
(O)
H Laouamri
(H)
K Souryis
(K)
S Hotier
(S)
A Pelletier
(A)
N Drancourt
(N)
J P Sanchez
(JP)
E Saliou
(E)
C Hebbache
(C)
J Petrucci
(J)
L Willaume
(L)
E Bourdin
(E)
F Bellivier
(F)
M Carminati
(M)
B Etain
(B)
E Marlinge
(E)
J Meheust
(J)
B Antoniol
(B)
A Desage
(A)
S Gard
(S)
A Jutant
(A)
K Mbailara
(K)
I Minois
(I)
L Zanouy
(L)
C Abettan
(C)
L Bardin
(L)
A Cazals
(A)
P Courtet
(P)
B Deffinis
(B)
D Ducasse
(D)
M Gachet
(M)
A Henrion
(A)
E Martinerie
(E)
F Molière
(F)
B Noisette
(B)
E Olié
(E)
G Tarquini
(G)
J M Azorin
(JM)
R Belzeaux
(R)
N Correard
(N)
J L Consoloni
(JL)
F Groppi
(F)
L Lescalier
(L)
J Montant
(J)
M Rebattu
(M)
N Viglianese
(N)
R Cohen
(R)
J P Kahn
(JP)
M Milazzo
(M)
O Wajsbrot-Elgrabli
(O)
T Bougerol
(T)
B Fredembach
(B)
A Suisse
(A)
B Halili
(B)
A Pouchon
(A)
M Polosan
(M)
A M Galliot
(AM)
I Grévin
(I)
A S Cannavo
(AS)
N Kayser
(N)
C Passerieux
(C)
P Roux
(P)
V Aubin
(V)
I Cussac
(I)
M A Dupont
(MA)
J Loftus
(J)
I Medecin
(I)
C Dubertret
(C)
N Mazer
(N)
C Portalier
(C)
C Scognamiglio
(C)
A Bing
(A)
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.