Dopamine D1 + D3 receptor density may correlate with parkinson disease clinical features.
Journal
Annals of clinical and translational neurology
ISSN: 2328-9503
Titre abrégé: Ann Clin Transl Neurol
Pays: United States
ID NLM: 101623278
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
22
08
2020
revised:
11
11
2020
accepted:
24
11
2020
pubmed:
22
12
2020
medline:
9
10
2021
entrez:
21
12
2020
Statut:
ppublish
Résumé
Dopamine D2-like receptors - mainly dopamine D2 receptors (D2R) and dopamine D3 receptors (D3R) - are believed to be greatly involved in the pathology of Parkinson disease (PD) progression. However, these receptors have not been precisely examined in PD patients. Our aim was to quantitatively calculate the exact densities of dopamine D1 receptors (D1R), D2R, and D3R in control, Alzheimer disease (AD), and Lewy body disease (LBD) patients (including PD, Dementia with Lewy bodies, and Parkinson disease dementia); and analyze the relationship between dopamine receptors and clinical PD manifestations. We analyzed the densities of D1R, D2R, and D3R in the striatum and substantia nigra (SN) using a novel quantitative autoradiography procedure previously developed by our group. We also examined the expression of D2R and D3R mRNA in the striatum by in situ hybridization. The results showed that although no differences of striatal D1R were found among all groups; D2R was significantly decreased in the striatum of PD patients when compared with control and AD patients. Some clinical manifestations: age of onset, PD stage, dopamine responsiveness, and survival time after onset; showed a better correlation with striatal D1R + D3R densities combined compared to D1R or D3R alone. There is a possibility that we may infer the results in diagnosis, treatment, and prognosis of PD by detecting D1R + D3R as opposed to using dopamine D1 or D3 receptors alone. This is especially true for elderly patients with low D2R expression as is common in this disease.
Identifiants
pubmed: 33348472
doi: 10.1002/acn3.51274
pmc: PMC7818081
doi:
Substances chimiques
Receptors, Dopamine D1
0
Receptors, Dopamine D2
0
Receptors, Dopamine D3
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
224-237Subventions
Organisme : NIA NIH HHS
ID : P30 AG066444
Pays : United States
Organisme : NIH HHS
ID : R01 AG052550
Pays : United States
Organisme : NIH HHS
ID : R01 NS092865
Pays : United States
Organisme : NIA NIH HHS
ID : R03 AG070474
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS092865
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS123571
Pays : United States
Organisme : NINDS NIH HHS
ID : R03 NS090214
Pays : United States
Organisme : NIH HHS
ID : P50 AG06644
Pays : United States
Informations de copyright
© 2020 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.
Références
Brain Res Bull. 2012 Apr 10;87(6):504-10
pubmed: 22421165
Cell Physiol Biochem. 2018;51(4):1600-1615
pubmed: 30497067
Neurobiol Dis. 2005 Nov;20(2):450-60
pubmed: 15896973
Nature. 1995 Oct 5;377(6548):424-8
pubmed: 7566118
J Neuroinflammation. 2018 Jan 04;15(1):2
pubmed: 29301581
J Neurosci Res. 2010 Aug 15;88(11):2513-23
pubmed: 20623619
Arq Bras Cir Dig. 2012 Jan-Mar;25(1):49-51
pubmed: 22569979
Mov Disord. 1997 Jan;12(1):33-8
pubmed: 8990051
Neurotox Res. 2013 Nov;24(4):523-31
pubmed: 23820985
J Neurochem. 2009 Feb;108(3):621-33
pubmed: 19187092
Biochim Biophys Acta. 2007 Apr;1768(4):871-87
pubmed: 17274946
Exp Neurol. 2004 Nov;190(1):157-70
pubmed: 15473989
Expert Opin Drug Discov. 2016 Jul;11(7):641-64
pubmed: 27135354
Brain Res. 2002 Nov 15;955(1-2):138-52
pubmed: 12419530
J Biol Chem. 2008 Sep 19;283(38):26016-25
pubmed: 18644790
Exp Neurol. 1997 Aug;146(2):604-8
pubmed: 9270075
Brain Res. 2007 Jul 30;1160:113-23
pubmed: 17573046
Front Pharmacol. 2014 Jul 10;5:161
pubmed: 25071579
Mol Neurobiol. 2019 May;56(5):3437-3450
pubmed: 30128652
Arch Neurol. 2004 Nov;61(11):1705-9
pubmed: 15534182
Proc Natl Acad Sci U S A. 2004 Aug 3;101(31):11465-70
pubmed: 15272078
Neurology. 2011 Aug 23;77(8):767-74
pubmed: 21832216
Mol Pharmacol. 2008 Jul;74(1):59-69
pubmed: 18424554
Synapse. 2010 Jun;64(6):449-59
pubmed: 20175227
Pharmacol Rev. 2011 Mar;63(1):182-217
pubmed: 21303898
Neurosci Lett. 2013 Dec 17;557 Pt B:123-8
pubmed: 24157858
Curr Opin Investig Drugs. 2001 Nov;2(11):1582-91
pubmed: 11763161
J Pharmacol Exp Ther. 2002 Nov;303(2):791-804
pubmed: 12388666
Brain. 2009 May;132(Pt 5):1366-75
pubmed: 19153147
Arch Neurol. 2001 Feb;58(2):249-54
pubmed: 11176963
Arch Neurol. 1995 Dec;52(12):1183-90
pubmed: 7492293
Neuropharmacology. 2018 Aug;138:304-314
pubmed: 29936243
Cell. 2015 Jan 15;160(1-2):62-73
pubmed: 25594175
Front Neurol. 2018 Jun 19;9:455
pubmed: 29971039
Folia Neuropathol. 2014;52(2):179-86
pubmed: 25118903
Neuroscience. 1999;91(3):911-24
pubmed: 10391470
Neurobiol Aging. 2014 Jul;35(7):1726-38
pubmed: 24529758
ChemMedChem. 2014 Dec;9(12):2653-60
pubmed: 25338762
FASEB J. 2005 Apr;19(6):583-5
pubmed: 15703272
Eur J Pharmacol. 2014 Feb 5;724:31-42
pubmed: 24365490
J Neurochem. 2013 Aug;126(4):529-40
pubmed: 23452092
Neuropharmacology. 2014 Apr;79:726-37
pubmed: 24333147
Ageing Res Rev. 2020 Jan;57:100994
pubmed: 31765822
Int J Med Chem. 2011;2011:403039
pubmed: 25954517
J Clin Invest. 2012 Nov;122(11):3977-89
pubmed: 23041629
CNS Neurol Disord Drug Targets. 2006 Jun;5(3):345-53
pubmed: 16787233
Eur J Neurosci. 2008 Oct;28(7):1231-40
pubmed: 18973551
J Pharmacol Exp Ther. 1992 Jul;262(1):383-93
pubmed: 1352553
Behav Brain Res. 2020 Jan 27;378:112304
pubmed: 31626851
Mol Neurobiol. 2018 Feb;55(2):1054-1067
pubmed: 28092083
Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):3363-7
pubmed: 9096399
Front Pharmacol. 2017 Dec 21;8:935
pubmed: 29311936
J Neurosci. 2006 Jul 5;26(27):7272-80
pubmed: 16822985
J Neurosci. 2007 May 16;27(20):5291-300
pubmed: 17507552
J Pharmacol Exp Ther. 1994 Feb;268(2):1015-23
pubmed: 8113958
Curr Med Chem. 2014;21(27):3188-210
pubmed: 24533801
CNS Drugs. 2010 Oct;24(10):829-41
pubmed: 20839895
Neuroreport. 2001 May 8;12(6):1175-9
pubmed: 11338187
Drug Discov Today. 2019 Jun;24(6):1295-1303
pubmed: 30974176
Neurobiol Dis. 2019 Jan;121:120-130
pubmed: 30261284