LncRNA-mRNA Co-Expression Analysis Identifies AL133346.1/CCN2 as Biomarkers in Pediatric B-Cell Acute Lymphoblastic Leukemia.
AL133346.1
CCN2
CTGF
biomarker
lncRNA expression
pediatric B-ALL
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
17 Dec 2020
17 Dec 2020
Historique:
received:
02
11
2020
revised:
10
12
2020
accepted:
15
12
2020
entrez:
22
12
2020
pubmed:
23
12
2020
medline:
23
12
2020
Statut:
epublish
Résumé
Pediatric acute B-cell lymphoblastic leukemia (B-ALL) constitutes a heterogeneous and aggressive neoplasia in which new targeted therapies are required. Long non-coding RNAs have recently emerged as promising disease-specific biomarkers for the clinic. Here, we identified pediatric B-ALL-specific lncRNAs and associated mRNAs by comparing the transcriptomic signatures of tumoral and non-tumoral samples. We identified 48 lncRNAs that were differentially expressed between pediatric B-ALL and healthy bone marrow samples. The most relevant lncRNA/mRNA pair was AL133346.1/CCN2 (previously known as RP11-69I8.3/CTGF), whose expression was positively correlated and increased in B-ALL samples. Their differential expression pattern and their strong correlation were validated in external B-ALL datasets (Therapeutically Applicable Research to Generate Effective Treatments, Cancer Cell Line Encyclopedia). Survival curve analysis demonstrated that patients with "high" expression levels of CCN2 had higher overall survival than those with "low" levels (
Identifiants
pubmed: 33348573
pii: cancers12123803
doi: 10.3390/cancers12123803
pmc: PMC7765782
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Spanish Ministry of Economy and Business
ID : SAF2015-67919-R
Organisme : Consejería de Salud de la Junta de Andalucía
ID : Pl-0245-2017; CS2016-3
Organisme : Asociación Española Contra el Cáncer (AECC) Foundation
ID : LabAECC-2018
Organisme : Programa Operativo FEDER 2018
ID : B-CTS-126-UGR18
Organisme : Fundación Benéfica Anticáncer Santa Cándida y San Francisco Javier
ID : Predoctoral Fellowship
Organisme : Spanish Ministry of Education, Culture and Sports FPU Felowship
ID : FPU17/00067; FPU17/01258
Organisme : La Caixa Foundation Fellowship
ID : LCF/BQ/DE15/10360019
Organisme : Marie Sklodowska Curie Actions Postdoctoral Fellowship
ID : H2020-MSCA-IF-2018
Organisme : Aula de Investigación sobre la Leucemia infantil: Héroes contra la Leucemia
ID : Aula2020
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