Gangliosides in Podocyte Biology and Disease.
ceramide
glomerulopathies
glomerulus
glycosphingolipids
kidney
nephrotic syndrome
podocytopathies
rafts
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
17 Dec 2020
17 Dec 2020
Historique:
received:
23
11
2020
revised:
07
12
2020
accepted:
14
12
2020
entrez:
22
12
2020
pubmed:
23
12
2020
medline:
19
3
2021
Statut:
epublish
Résumé
Gangliosides constitute a subgroup of glycosphingolipids characterized by the presence of sialic acid residues in their structure. As constituents of cellular membranes, in particular of raft microdomains, they exert multiple functions, some of them capital in cell homeostasis. Their presence in cells is tightly regulated by a balanced expression and function of the enzymes responsible for their biosynthesis, ganglioside synthases, and their degradation, glycosidases. The dysregulation of their abundance results in rare and common diseases. In this review, we make a point on the relevance of gangliosides and some of their metabolic precursors, such as ceramides, in the function of podocytes, the main cellular component of the glomerular filtration barrier, as well as their implications in podocytopathies. The results presented in this review suggest the pertinence of clinical lipidomic studies targeting these metabolites.
Identifiants
pubmed: 33348903
pii: ijms21249645
doi: 10.3390/ijms21249645
pmc: PMC7766259
pii:
doi:
Substances chimiques
Gangliosides
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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