Silent cerebral infarcts in patients with sickle cell disease: a systematic review and meta-analysis.
Magnetic resonance imaging
Sickle cell disease
Silent cerebral infarction
Stroke
Journal
BMC medicine
ISSN: 1741-7015
Titre abrégé: BMC Med
Pays: England
ID NLM: 101190723
Informations de publication
Date de publication:
22 12 2020
22 12 2020
Historique:
received:
30
07
2020
accepted:
22
11
2020
entrez:
22
12
2020
pubmed:
23
12
2020
medline:
27
2
2021
Statut:
epublish
Résumé
Silent cerebral infarcts (SCIs) are the most common neurological complication in children and adults with sickle cell disease (SCD). In this systematic review, we provide an overview of studies that have detected SCIs in patients with SCD by cerebral magnetic resonance imaging (MRI). We focus on the frequency of SCIs, the risk factors involved in their development and their clinical consequences. The databases of Embase, MEDLINE ALL via Ovid, Web of Science Core Collection, Cochrane Central Register of Trials via Wiley and Google Scholar were searched from inception to June 1, 2019. The search yielded 651 results of which 69 studies met the eligibility criteria. The prevalence of SCIs in patients with SCD ranges from 5.6 to 80.6% with most studies reported in the 20 to 50% range. The pooled prevalence of SCIs in HbSS and HbSβ This systematic review and meta-analysis shows SCIs are common in patients with SCD. No clear risk factors for their development were identified. Larger, prospective and controlled clinical, neuropsychological and neuroimaging studies are needed to understand how SCD and SCIs affect cognition.
Sections du résumé
BACKGROUND AND PURPOSE
Silent cerebral infarcts (SCIs) are the most common neurological complication in children and adults with sickle cell disease (SCD). In this systematic review, we provide an overview of studies that have detected SCIs in patients with SCD by cerebral magnetic resonance imaging (MRI). We focus on the frequency of SCIs, the risk factors involved in their development and their clinical consequences.
METHODS
The databases of Embase, MEDLINE ALL via Ovid, Web of Science Core Collection, Cochrane Central Register of Trials via Wiley and Google Scholar were searched from inception to June 1, 2019.
RESULTS
The search yielded 651 results of which 69 studies met the eligibility criteria. The prevalence of SCIs in patients with SCD ranges from 5.6 to 80.6% with most studies reported in the 20 to 50% range. The pooled prevalence of SCIs in HbSS and HbSβ
CONCLUSIONS
This systematic review and meta-analysis shows SCIs are common in patients with SCD. No clear risk factors for their development were identified. Larger, prospective and controlled clinical, neuropsychological and neuroimaging studies are needed to understand how SCD and SCIs affect cognition.
Identifiants
pubmed: 33349253
doi: 10.1186/s12916-020-01864-8
pii: 10.1186/s12916-020-01864-8
pmc: PMC7754589
doi:
Types de publication
Journal Article
Meta-Analysis
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
393Références
Blood. 2016 Apr 21;127(16):2038-40
pubmed: 26941400
Indian J Radiol Imaging. 2018 Jul-Sep;28(3):305-311
pubmed: 30319206
JAMA. 2010 May 12;303(18):1823-31
pubmed: 20460621
Dev Sci. 2006 Jul;9(4):379-87
pubmed: 16764611
Adv Med Sci. 2014 Mar;59(1):108-13
pubmed: 24797985
JAMA. 2014 Sep 10;312(10):1033-48
pubmed: 25203083
Eur J Pediatr. 1995 Feb;154(2):150-6
pubmed: 7720746
J Int Neuropsychol Soc. 2006 Jan;12(1):24-33
pubmed: 16433941
Blood. 2012 Apr 19;119(16):3684-90
pubmed: 22096242
Arch Neurol. 2001 Dec;58(12):2017-21
pubmed: 11735775
Blood. 2011 Jan 27;117(4):1130-40; quiz 1436
pubmed: 21068435
Blood. 2015 Mar 5;125(10):1653-61
pubmed: 25533032
Radiology. 2003 May;227(2):567-74
pubmed: 12663827
Hematol Rep. 2013 Feb 05;5(1):8-12
pubmed: 23888239
Radiology. 1993 Nov;189(2):457-66
pubmed: 8105505
Br J Haematol. 2016 Jan;172(2):274-84
pubmed: 26492630
Pediatr Blood Cancer. 2018 Jan;65(1):
pubmed: 28834316
J Biol Chem. 1977 Jul 25;252(14):5019-31
pubmed: 873928
Haematologica. 2019 Apr;104(4):690-699
pubmed: 30523051
Blood. 2011 Jul 28;118(4):894-8
pubmed: 21633086
Blood Adv. 2017 Dec 01;1(26):2503-2509
pubmed: 29296901
Brain Connect. 2017 Sep;7(7):443-453
pubmed: 28747064
JAMA Neurol. 2013 Jan;70(1):58-65
pubmed: 23108767
Br J Haematol. 2012 Nov;159(3):352-9
pubmed: 22958163
Pediatr Blood Cancer. 2009 Jan;52(1):85-91
pubmed: 18937311
Blood. 2016 Feb 18;127(7):829-38
pubmed: 26758917
J Magn Reson Imaging. 2012 Apr;35(4):779-87
pubmed: 22095695
Pediatr Hematol Oncol. 2010 Mar;27(2):69-89
pubmed: 20201689
JAMA. 2014 Sep 10;312(10):1004-5
pubmed: 25203081
Br J Haematol. 2009 Aug;146(3):300-5
pubmed: 19500105
Pediatr Hematol Oncol. 2008 Jun;25(5):409-21
pubmed: 18569843
Pediatrics. 1999 Mar;103(3):640-5
pubmed: 10049969
J Pediatr. 2001 Sep;139(3):385-90
pubmed: 11562618
Blood. 2013 Dec 5;122(24):3892-8
pubmed: 24052549
J Child Neurol. 2006 Jan;21(1):37-44
pubmed: 16551451
Pediatrics. 1996 Jun;97(6 Pt 1):864-70
pubmed: 8657528
EClinicalMedicine. 2019 May 24;11:27-33
pubmed: 31312804
Lancet Neurol. 2007 Jul;6(7):611-9
pubmed: 17582361
Dev Med Child Neurol. 1998 Aug;40(8):536-43
pubmed: 9746006
Dev Med Child Neurol. 2016 Jul;58(7):672-9
pubmed: 27038278
J R Coll Physicians Edinb. 2017 Sep;47(3):271-275
pubmed: 29465106
J Pediatr Psychol. 2002 Dec;27(8):739-48
pubmed: 12403864
Blood. 2012 Nov 8;120(19):3891-7
pubmed: 22948048
Stroke. 2009 Jul;40(7):2408-12
pubmed: 19443807
J Child Neurol. 2000 May;15(5):333-43
pubmed: 10830200
J Pediatr. 2001 Sep;139(3):391-7
pubmed: 11562619
Syst Rev. 2015 Jan 01;4:1
pubmed: 25554246
Stroke. 2014 Oct;45(10):2863-7
pubmed: 25139879
Am J Hematol. 2011 Jan;86(1):104-6
pubmed: 21117059
NMR Biomed. 2018 Jun;31(6):e3915
pubmed: 29601112
Ann Neurol. 2004 Jun;55(6):835-9
pubmed: 15174017
J Pediatr. 1998 Jun;132(6):994-8
pubmed: 9627592
Lancet. 2013 Jan 12;381(9861):142-51
pubmed: 23103089
Pediatr Blood Cancer. 2008 Nov;51(5):643-6
pubmed: 18478575
PLoS One. 2012;7(1):e29786
pubmed: 22253781
Br J Haematol. 2016 Oct;175(2):331-338
pubmed: 27604981
N Engl J Med. 2014 Aug 21;371(8):699-710
pubmed: 25140956
Br J Haematol. 2015 Feb;168(4):553-6
pubmed: 25303108
Am J Hematol. 2003 Aug;73(4):240-3
pubmed: 12879426
Br J Haematol. 2015 Oct;171(1):120-9
pubmed: 26058476
J Pediatr Hematol Oncol. 2000 Jul-Aug;22(4):335-9
pubmed: 10959904
AJNR Am J Neuroradiol. 1996 May;17(5):965-72
pubmed: 8733975
Pediatr Blood Cancer. 2014 Jan;61(1):25-8
pubmed: 24038756
Blood. 2015 Jan 8;125(2):416-7
pubmed: 25573975
Ann Neurol. 2006 Apr;59(4):662-72
pubmed: 16450382
Cerebrovasc Dis. 2015;39(3-4):181-9
pubmed: 25765995
Tohoku J Exp Med. 2006 Jun;209(2):135-40
pubmed: 16707855
Neurology. 2018 Aug 21;91(8):e781-e784
pubmed: 30054441
Radiology. 2003 Jul;228(1):216-25
pubmed: 12775848
J Pediatr Psychol. 2000 Oct-Nov;25(7):503-13
pubmed: 11007807
Haematologica. 2018 Jul;103(7):1136-1142
pubmed: 29545349
Blood. 2018 Oct 18;132(16):1714-1723
pubmed: 30061156
BMC Med. 2014 Jul 09;12:119
pubmed: 25012298
J Child Neurol. 2005 Feb;20(2):102-7
pubmed: 15794173
Blood. 2002 Apr 15;99(8):3014-8
pubmed: 11929794
Blood. 2012 May 17;119(20):4587-96
pubmed: 22354000
Am J Hematol. 2018 Jun;93(6):760-768
pubmed: 29520844