T cell phenotypes associated with insulin resistance: results from the Berlin Aging Study II.
Aging
Insulin resistance
Obesity
Systemic inflammation
T cell senescence
Journal
Immunity & ageing : I & A
ISSN: 1742-4933
Titre abrégé: Immun Ageing
Pays: England
ID NLM: 101235427
Informations de publication
Date de publication:
21 Dec 2020
21 Dec 2020
Historique:
received:
26
07
2020
accepted:
30
11
2020
entrez:
22
12
2020
pubmed:
23
12
2020
medline:
23
12
2020
Statut:
epublish
Résumé
Obesity is associated with chronic low-grade inflammation leading to metabolic and cardiovascular diseases, but a subset of obese individuals is considered insulin sensitive (IS). The underlying pathophysiologic mechanisms remain elusive and clinical studies on the relationship between inflammatory markers and metabolically healthy obesity (MHO) are scarce. In this cross-sectional analysis, we included a sample of 437 older participants (60-84 years) from the Berlin Aging Study II (BASE-II). Peripheral blood mononuclear cells were isolated, immune cell subsets were analyzed with multiparameter flow cytometry and systemic cytokine levels were measured. Immune cell parameters were correlated with metabolic measures and multiple linear regression analysis was conducted and adjusted for various demographic and clinical factors. We found that frequencies of naïve and memory CD4 These findings support the hypothesis that parameters of systemic inflammation can differentiate IS from IR obese individuals that are at higher risk for cardiometabolic diseases and may have clinical implications with regard to obesity treatment stratification. DRKS00009277 . Registered 31 August 2015 - Retrospectively registered.
Sections du résumé
BACKGROUND
BACKGROUND
Obesity is associated with chronic low-grade inflammation leading to metabolic and cardiovascular diseases, but a subset of obese individuals is considered insulin sensitive (IS). The underlying pathophysiologic mechanisms remain elusive and clinical studies on the relationship between inflammatory markers and metabolically healthy obesity (MHO) are scarce.
METHODS
METHODS
In this cross-sectional analysis, we included a sample of 437 older participants (60-84 years) from the Berlin Aging Study II (BASE-II). Peripheral blood mononuclear cells were isolated, immune cell subsets were analyzed with multiparameter flow cytometry and systemic cytokine levels were measured. Immune cell parameters were correlated with metabolic measures and multiple linear regression analysis was conducted and adjusted for various demographic and clinical factors.
RESULTS
RESULTS
We found that frequencies of naïve and memory CD4
CONCLUSIONS
CONCLUSIONS
These findings support the hypothesis that parameters of systemic inflammation can differentiate IS from IR obese individuals that are at higher risk for cardiometabolic diseases and may have clinical implications with regard to obesity treatment stratification.
TRIAL REGISTRATION
BACKGROUND
DRKS00009277 . Registered 31 August 2015 - Retrospectively registered.
Identifiants
pubmed: 33349270
doi: 10.1186/s12979-020-00211-y
pii: 10.1186/s12979-020-00211-y
pmc: PMC7751110
doi:
Types de publication
Journal Article
Langues
eng
Pagination
40Subventions
Organisme : Bundesministerium für Bildung und Forschung
ID : #16SV5536K, #16SV5537, #16SV5538, #16SV5837, #01UW0808, 01GL1716A, and 01GL1716B
Références
Clin Cancer Res. 2014 Mar 15;20(6):1601-9
pubmed: 24323899
J Gerontol A Biol Sci Med Sci. 2016 Sep;71(9):1117-23
pubmed: 26615178
Arterioscler Thromb Vasc Biol. 2014 Dec;34(12):2637-43
pubmed: 25341798
J Clin Invest. 2006 Jul;116(7):1793-801
pubmed: 16823477
Biogerontology. 2016 Feb;17(1):189-98
pubmed: 25906063
Cell. 2004 Jan 23;116(2):337-50
pubmed: 14744442
Nat Med. 2012 Sep;18(9):1407-12
pubmed: 22863787
Metabolism. 2014 Apr;63(4):492-501
pubmed: 24467914
Diabetes. 2003 Mar;52(3):812-7
pubmed: 12606524
Interdiscip Top Gerontol. 2014;39:163-76
pubmed: 24862019
Nat Med. 2011 May;17(5):610-7
pubmed: 21499269
J Health Care Poor Underserved. 2011;22(4 Suppl):61-72
pubmed: 22102306
BMC Endocr Disord. 2014 Feb 01;14:9
pubmed: 24484869
Nat Med. 2009 Aug;15(8):930-9
pubmed: 19633656
Am J Clin Nutr. 2016 Jan;103(1):178-83
pubmed: 26675777
Immunity. 2014 Jul 17;41(1):36-48
pubmed: 25035952
Exp Gerontol. 2020 Feb 22;134:110887
pubmed: 32092501
PLoS One. 2018 Jan 31;13(1):e0191699
pubmed: 29385202
Eur J Immunol. 2020 Mar;50(3):363-379
pubmed: 31755098
PLoS One. 2014 Jan 17;9(1):e85770
pubmed: 24465695
Transplant Res. 2013 Oct 25;2(1):17
pubmed: 24160259
Sci Rep. 2015 Nov 19;5:16801
pubmed: 26582486
Obes Rev. 2020 Apr;21(4):e12991
pubmed: 32020741
BMC Public Health. 2009 Mar 25;9:88
pubmed: 19320986
Am J Physiol Endocrinol Metab. 2010 Sep;299(3):E506-15
pubmed: 20570822
Neurobiol Aging. 2016 Feb;38:112-117
pubmed: 26827649
J Immunol. 2010 Oct 15;185(8):4618-24
pubmed: 20855876
Nature. 2006 Dec 14;444(7121):881-7
pubmed: 17167477
Int J Epidemiol. 2014 Jun;43(3):703-12
pubmed: 23505255
Nat Med. 2009 Aug;15(8):914-20
pubmed: 19633658
J Endocrinol. 2014 Nov;223(2):R41-8
pubmed: 25228503
Immun Ageing. 2013 Apr 02;10(1):12
pubmed: 23547999
Nat Rev Cancer. 2004 Aug;4(8):579-91
pubmed: 15286738
Obesity (Silver Spring). 2013 Mar;21(3):461-8
pubmed: 23592653
Eur J Clin Nutr. 2017 Nov;71(11):1256-1258
pubmed: 28952604
J Chronic Dis. 1987;40(5):373-83
pubmed: 3558716
Diabetes. 2006 Oct;55(10):2688-97
pubmed: 17003332
J Am Coll Cardiol. 2018 Sep 25;72(13):1506-1531
pubmed: 30236314
J Immunol. 2020 Jul 1;205(1):45-55
pubmed: 32482712
Thyroid. 2019 Sep;29(9):1220-1226
pubmed: 31426720
Nat Med. 2009 Aug;15(8):940-5
pubmed: 19633655
Immun Ageing. 2020 May 27;17:15
pubmed: 32514279
Diabetes Obes Metab. 2013 Sep;15 Suppl 3:34-8
pubmed: 24003919
Immunol Res. 2018 Apr;66(2):234-244
pubmed: 29560551
Diabetes Care. 1999 Sep;22(9):1462-70
pubmed: 10480510
Cytometry A. 2016 Jun;89(6):543-64
pubmed: 27144459
Endocr Rev. 2020 May 1;41(3):
pubmed: 32128581
Lancet Diabetes Endocrinol. 2019 Sep;7(9):715-725
pubmed: 31301983
Best Pract Res Clin Endocrinol Metab. 2013 Apr;27(2):163-77
pubmed: 23731879
Gerontology. 2016;62(3):323-9
pubmed: 26820888
Gerontology. 2016;62(3):311-5
pubmed: 26820471
J Clin Invest. 2013 Dec;123(12):4992-3
pubmed: 24292661
Eur J Immunol. 2019 Feb;49(2):336-347
pubmed: 30566246
Gastroenterology. 2013 Aug;145(2):366-74.e1-3
pubmed: 23597726
Blood. 2003 Apr 1;101(7):2711-20
pubmed: 12433688
Circulation. 2007 Feb 27;115(8):1029-38
pubmed: 17296858
Diabetes. 2012 Sep;61(9):2330-9
pubmed: 22851575
Immun Ageing. 2019 May 21;16:11
pubmed: 31139232
Curr Opin Lipidol. 2010 Feb;21(1):38-43
pubmed: 19915462
Biogerontology. 2015 Oct;16(5):631-43
pubmed: 25732234