Essential interpretations of bioinformatics in COVID-19 pandemic.
Bioinformatics
COVID-19
Drug design
Genome wide association study
Next generation sequencing
SARS-CoV-2
Journal
Meta gene
ISSN: 2214-5400
Titre abrégé: Meta Gene
Pays: Netherlands
ID NLM: 101627670
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
received:
18
10
2020
revised:
02
12
2020
accepted:
14
12
2020
pubmed:
23
12
2020
medline:
23
12
2020
entrez:
22
12
2020
Statut:
ppublish
Résumé
The currently emerging pathogen SARS-CoV-2 has produced the global pandemic crisis by causing COVID-19. The unique and novel genetic makeup of SARS-CoV-2 has created hurdles in biological research, due to which the potential drug/vaccine candidates have not yet been discovered by the scientific community. Meanwhile, the advantages of bioinformatics in viral research had created a milestone since last few decades. The exploitation of bioinformatics tools and techniques has successfully interpreted this viral genomics architecture. Some major in silico studies involving next-generation sequencing, genome-wide association studies, computer-aided drug design etc. have been effectively applied in COVID-19 research methodologies and discovered novel information on SARS-CoV-2 in several ways. Nowadays the implementation of in silico studies in COVID-19 research has not only sequenced the SARS-CoV-2 genome but also properly analyzed the sequencing errors, evolutionary relationship, genetic variations, putative drug candidates against SARS-CoV-2 viral genes etc. within a very short time period. These would be very needful towards further research on COVID-19 pandemic and essential for vaccine development against SARS-CoV-2 which will save public health.
Identifiants
pubmed: 33349792
doi: 10.1016/j.mgene.2020.100844
pii: S2214-5400(20)30199-7
pmc: PMC7744275
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
100844Informations de copyright
© 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
The authors declare that they have no conflict of interest.
Références
Methods Mol Biol. 2016;1418:93-110
pubmed: 27008011
Curr Protoc Bioinformatics. 2009 Dec;Chapter 1:Unit1.4
pubmed: 19957273
Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W363-7
pubmed: 15980490
Curr Protoc Bioinformatics. 2011 Dec;Chapter 10:10.7.1-10.7.20
pubmed: 22161565
Indian J Med Res. 2020 Feb & Mar;151(2 & 3):200-209
pubmed: 32242873
PLoS Comput Biol. 2016 May 25;12(5):e1004962
pubmed: 27224906
Mol Biol Evol. 2017 Dec 1;34(12):3299-3302
pubmed: 29029172
Med J Aust. 2020 Jun;212(10):459-462
pubmed: 32237278
Microb Genom. 2021 Dec;7(12):
pubmed: 34870573
N Engl J Med. 2020 Oct 15;383(16):1522-1534
pubmed: 32558485
Microbiol Resour Announc. 2020 May 14;9(20):
pubmed: 32409547
Sci Adv. 2020 Jul 10;6(28):eabb8097
pubmed: 32691011
Nucleic Acids Res. 2013 Jul;41(Web Server issue):W29-33
pubmed: 23609542
J Comput Chem. 2004 Oct;25(13):1605-12
pubmed: 15264254
Bioinformatics. 2013 Nov 1;29(21):2669-77
pubmed: 23990416
Pathogens. 2020 Jul 17;9(7):
pubmed: 32708840
Nucleic Acids Res. 2001 Jan 1;29(1):308-11
pubmed: 11125122
Infect Genet Evol. 2020 Oct;84:104451
pubmed: 32640381
Gene Rep. 2020 Jun;19:100682
pubmed: 32300673
J Comput Aided Mol Des. 2010 May;24(5):417-22
pubmed: 20401516
Int J Antimicrob Agents. 2020 May;55(5):105960
pubmed: 32251731
Nucleic Acids Res. 2008 Jan;36(Database issue):D190-5
pubmed: 18045787
Bioinformatics. 2017 Jun 9;33(19):3137-3139
pubmed: 28605449
Virus Res. 2020 Jul 2;283:197963
pubmed: 32278821
J Biomol Struct Dyn. 2021 Apr;39(7):2617-2627
pubmed: 32238078
Genomics Inform. 2020 Dec;18(4):e43
pubmed: 33412759
Chin J Integr Med. 2020 Sep;26(9):663-669
pubmed: 32740825
Mol Inform. 2021 Jan;40(1):e2000115
pubmed: 32722864
Nucleic Acids Res. 2000 Jan 1;28(1):235-42
pubmed: 10592235
J Med Chem. 2004 Mar 25;47(7):1739-49
pubmed: 15027865
Nat Protoc. 2016 May;11(5):905-19
pubmed: 27077332
Nan Fang Yi Ke Da Xue Xue Bao. 2020 Feb 29;40(2):152-158
pubmed: 32376535
J Biomed Sci. 2020 Jun 7;27(1):73
pubmed: 32507105
Sci Rep. 2019 Mar 1;9(1):3219
pubmed: 30824715
J Comput Chem. 2005 Dec;26(16):1781-802
pubmed: 16222654
J Enzyme Inhib Med Chem. 2020 Dec;35(1):1539-1544
pubmed: 32746637
Nucleic Acids Res. 2015 Jan;43(Database issue):D36-42
pubmed: 25355515
Front Genet. 2019 Feb 12;10:49
pubmed: 30809243
Nucleic Acids Res. 2007 Jul;35(Web Server issue):W169-75
pubmed: 17576678
J Transl Med. 2020 Jun 10;18(1):233
pubmed: 32522207
Sci Rep. 2021 Jan 13;11(1):947
pubmed: 33441822
Nucleic Acids Res. 2008 Jul 1;36(Web Server issue):W465-9
pubmed: 18424797
Nucleic Acids Res. 2011 Jul;39(Web Server issue):W270-7
pubmed: 21624888
Travel Med Infect Dis. 2020 May - Jun;35:101646
pubmed: 32294562
Sci Rep. 2021 Jun 15;11(1):12565
pubmed: 34131209
Nucleic Acids Res. 2012 Aug;40(15):e115
pubmed: 22730293
Nucleic Acids Res. 2012 Jul;40(Web Server issue):W452-7
pubmed: 22689647
J Biomol Struct Dyn. 2021 May;39(8):2724-2732
pubmed: 32266867
Front Microbiol. 2020 Jun 05;11:1316
pubmed: 32582136
Clin Chem. 2020 Jul 1;66(7):966-972
pubmed: 32379863
J Cheminform. 2016 Jun 10;8:32
pubmed: 27293485
Nature. 2020 Jul;583(7815):282-285
pubmed: 32218527
Emerg Microbes Infect. 2020 Dec;9(1):313-319
pubmed: 32020836
J Comput Chem. 2010 Jan 30;31(2):455-61
pubmed: 19499576
Bioinformatics. 2014 Jun 15;30(12):i302-9
pubmed: 24931998
J Biomol Struct Dyn. 2021 Aug;39(13):4618-4632
pubmed: 32567989
PLoS One. 2019 Dec 5;14(12):e0220215
pubmed: 31805043
Nucleic Acids Res. 2011 Jan;39(Database issue):D19-21
pubmed: 21062823
Microbiol Resour Announc. 2020 Mar 12;9(11):
pubmed: 32165386
Genet Mol Biol. 2017 Jul-Sep 01;40(3):553-576
pubmed: 28898352
Front Genet. 2018 Nov 27;9:575
pubmed: 30538723
BMC Bioinformatics. 2012 Jun 18;13:134
pubmed: 22708584
Microb Inform Exp. 2012 Feb 09;2(1):3
pubmed: 22587947
Comput Biol Med. 2020 Sep;124:103936
pubmed: 32738628
J Infect. 2020 Aug;81(2):e175-e177
pubmed: 32562797
Brief Bioinform. 2009 Sep;10(5):579-91
pubmed: 19433475
J Cheminform. 2011 Oct 07;3:33
pubmed: 21982300
Virology. 2019 May;531:141-148
pubmed: 30878524
mSphere. 2020 May 6;5(3):
pubmed: 32376697
Curr Protoc Bioinformatics. 2003 Feb;Chapter 6:Unit 6.4
pubmed: 18428704
Curr Protoc Bioinformatics. 2008 Dec;Chapter 5:Unit 5.7
pubmed: 19085979
Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W465-7
pubmed: 15980513
Infect Genet Evol. 2020 Oct;84:104387
pubmed: 32485332
Braz J Microbiol. 2020 Dec;51(4):1593-1599
pubmed: 32592038
F1000Res. 2020 Jul 1;9:663
pubmed: 32765844
Nucleic Acids Res. 2011 Jan;39(Database issue):D28-31
pubmed: 20972220
Gut. 2021 Feb;70(2):276-284
pubmed: 32690600
Nucleic Acids Res. 2000 Jan 1;28(1):27-30
pubmed: 10592173
Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082
pubmed: 29126136
Brief Bioinform. 2008 Jul;9(4):299-306
pubmed: 18417537
Curr Protoc Bioinformatics. 2006 Oct;Chapter 5:Unit-5.6
pubmed: 18428767
PLoS One. 2011;6(9):e24657
pubmed: 21949741
Nat Rev Genet. 2019 Aug;20(8):467-484
pubmed: 31068683
Bioinformatics. 2014 Jul 15;30(14):2068-9
pubmed: 24642063
J Infect Public Health. 2020 Sep;13(9):1210-1223
pubmed: 32561274