Iatrogenic allergic contact dermatitis in the (peri)anal and genital area.
Adolescent
Adrenal Cortex Hormones
/ adverse effects
Adult
Aged
Anesthetics, Local
/ adverse effects
Anus Diseases
/ chemically induced
Benzoic Acid
/ adverse effects
Child
Child, Preschool
Cosmetics
/ adverse effects
Dermatitis, Allergic Contact
/ etiology
Female
Genital Diseases, Female
/ chemically induced
Genital Diseases, Male
/ chemically induced
Humans
Hygiene
Infant
Lanolin
/ adverse effects
Male
Middle Aged
Preservatives, Pharmaceutical
/ adverse effects
Retrospective Studies
Young Adult
allergic contact dermatitis
anal
genital
iatrogenic
perianal
topical drugs
vulvar
Journal
Contact dermatitis
ISSN: 1600-0536
Titre abrégé: Contact Dermatitis
Pays: England
ID NLM: 7604950
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
revised:
06
12
2020
received:
30
10
2020
accepted:
10
12
2020
pubmed:
23
12
2020
medline:
5
11
2021
entrez:
22
12
2020
Statut:
ppublish
Résumé
Allergic contact dermatitis (ACD) from topical medication often occurs in occluded areas, for example, with wound treatment, but also in certain body locations, such as the anogenital area. To investigate the demographics and specific lesion location of patients with ACD from topical drugs applied onto the (peri)anal/genital area, and to identify the respective causal topical pharmaceutical products and ingredients involved. From January 2000 to December 10, 2018, 532 patients were tested with the baseline series, sometimes with additional series, and the topical medication used along with the ingredients. The relevant data were extracted from our electronic databases developed in-house. Forty-four patients (9%) out of 473 patients suffering from lesions in the (peri)anal/genital area had positive patch test results to topical drug preparations and/or their ingredients, sometimes in association with cosmetics for intimate hygiene. The most frequent sensitizing active principles were local anaesthetics and corticosteroids, while wool alcohols and to a minor extent benzoic acid were the most frequent culprits among the vehicle components and preservative agents, respectively. The local conditions (eg, occlusion, sweating, moist) in the anogenital area may favour skin sensitization to topical medication used to treat various skin diseases.
Sections du résumé
BACKGROUND
BACKGROUND
Allergic contact dermatitis (ACD) from topical medication often occurs in occluded areas, for example, with wound treatment, but also in certain body locations, such as the anogenital area.
OBJECTIVES
OBJECTIVE
To investigate the demographics and specific lesion location of patients with ACD from topical drugs applied onto the (peri)anal/genital area, and to identify the respective causal topical pharmaceutical products and ingredients involved.
METHODS
METHODS
From January 2000 to December 10, 2018, 532 patients were tested with the baseline series, sometimes with additional series, and the topical medication used along with the ingredients. The relevant data were extracted from our electronic databases developed in-house.
RESULTS
RESULTS
Forty-four patients (9%) out of 473 patients suffering from lesions in the (peri)anal/genital area had positive patch test results to topical drug preparations and/or their ingredients, sometimes in association with cosmetics for intimate hygiene. The most frequent sensitizing active principles were local anaesthetics and corticosteroids, while wool alcohols and to a minor extent benzoic acid were the most frequent culprits among the vehicle components and preservative agents, respectively.
CONCLUSIONS
CONCLUSIONS
The local conditions (eg, occlusion, sweating, moist) in the anogenital area may favour skin sensitization to topical medication used to treat various skin diseases.
Substances chimiques
Adrenal Cortex Hormones
0
Anesthetics, Local
0
Cosmetics
0
Preservatives, Pharmaceutical
0
Lanolin
8006-54-0
Benzoic Acid
8SKN0B0MIM
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
431-438Informations de copyright
© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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