Gpr37l1/prosaposin receptor regulates Ptch1 trafficking, Shh production, and cell proliferation in cerebellar primary astrocytes.
G protein‐coupled receptor
RRID:AB_10709580
RRID:AB_10844948
RRID:AB_11000053
RRID:AB_11204167
RRID:AB_11205039
RRID:AB_141373
RRID:AB_141607
RRID:AB_141788
RRID:AB_162543
RRID:AB_1839970
RRID:AB_1904103
RRID:AB_2059853
RRID:AB_2060867
RRID:AB_2072166
RRID:AB_2109645
RRID:AB_2174039
RRID:AB_2174045
RRID:AB_2239686
RRID:AB_2245173
RRID:AB_2300649
RRID:AB_2534102
RRID:AB_2535792
RRID:AB_2536180
RRID:AB_2857918
RRID:AB_330744
RRID:AB_331646
RRID:AB_396365
RRID:AB_631728
RRID:AB_632416
RRID:AB_772207
RRID:AB_772210
RRID:AB_839154
RRID:AB_839504
RRID:MGI:5512669
RRID:SCR_002789
RRID:SCR_003070
RRID:SCR_003238
RRID:SCR_007370
RRID:SCR_010279
RRID:SCR_013673
RRID:SCR_014199
RRID:SCR_014210
cholesterol
mouse mutant
primary cilium
Journal
Journal of neuroscience research
ISSN: 1097-4547
Titre abrégé: J Neurosci Res
Pays: United States
ID NLM: 7600111
Informations de publication
Date de publication:
17 Dec 2020
17 Dec 2020
Historique:
received:
18
11
2020
accepted:
30
11
2020
entrez:
22
12
2020
pubmed:
23
12
2020
medline:
23
12
2020
Statut:
aheadofprint
Résumé
Mammalian cerebellar astrocytes critically regulate the differentiation and maturation of neuronal Purkinje cells and granule precursors. The G protein-coupled receptor 37-like 1 (Gpr37l1) is expressed by Bergmann astrocytes and interacts with patched 1 (Ptch1) at peri-ciliary membranes. Cerebellar primary astrocyte cultures from wild-type and Gpr37l1 null mutant mouse pups were established and studied. Primary cilia were produced by cultures of both genotypes, as well as Ptch1 and smoothened (Smo) components of the sonic hedgehog (Shh) mitogenic pathway. Compared to wild-type cells, Gpr37l1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : European Commission
Organisme : Consiglio Nazionale delle Ricerche
Informations de copyright
© 2020 Wiley Periodicals LLC.
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