Increase in Kelch 13 Polymorphisms in Plasmodium falciparum, Southern Rwanda.
Kelch
Plasmodium falciparum
antimicrobial resistance
artemisinin
malaria
mutation
parasites
polymorphism
vector-borne infections
Journal
Emerging infectious diseases
ISSN: 1080-6059
Titre abrégé: Emerg Infect Dis
Pays: United States
ID NLM: 9508155
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
entrez:
22
12
2020
pubmed:
23
12
2020
medline:
22
6
2021
Statut:
ppublish
Résumé
Artemisinin resistance in Plasmodium falciparum is associated with nonsynonymous mutations in the Kelch 13 (K13) propeller domain. We found that 12.1% (8/66) of clinical P. falciparum isolates from Huye district, Rwanda, exhibited K13 mutations, including R561H, a validated resistance marker. K13 mutations appear to be increasing in this region.
Identifiants
pubmed: 33350925
doi: 10.3201/eid2701.203527
pmc: PMC7774571
doi:
Substances chimiques
Antimalarials
0
Protozoan Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
294-296Références
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