Potential Molecular Targets in the Setting of Chemoradiation for Esophageal Malignancies.
Journal
Journal of the National Cancer Institute
ISSN: 1460-2105
Titre abrégé: J Natl Cancer Inst
Pays: United States
ID NLM: 7503089
Informations de publication
Date de publication:
01 06 2021
01 06 2021
Historique:
received:
16
07
2020
revised:
03
10
2020
accepted:
30
11
2020
pubmed:
23
12
2020
medline:
25
2
2022
entrez:
22
12
2020
Statut:
ppublish
Résumé
Although the development of effective combined chemoradiation regimens for esophageal cancers has resulted in statistically significant survival benefits, the majority of patients treated with curative intent develop locoregional and/or distant relapse. Further improvements in disease control and survival will require the development of individualized therapy based on the knowledge of host and tumor genomics and potentially harnessing the host immune system. Although there are a number of gene targets that are amplified and proteins that are overexpressed in esophageal cancers, attempts to target several of these have not proven successful in unselected patients. Herein, we review our current state of knowledge regarding the molecular pathways implicated in esophageal carcinoma, and the available agents for targeting these pathways that may rationally be combined with standard chemoradiation, with the hope that this commentary will guide future efforts of novel combinations of therapy.
Identifiants
pubmed: 33351071
pii: 6044199
doi: 10.1093/jnci/djaa195
pmc: PMC8600025
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
665-679Subventions
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Informations de copyright
Published by Oxford University Press 2020.
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