Dissociation of humoral and cellular immune responses in kidney transplant recipients with EBV mucocutaneous ulcer.
EBV positive mucocutaneous ulcer
Epstein-Barr virus
Post-transplant lymphoproliferative disorder
dissociated immune response
Journal
Transplant infectious disease : an official journal of the Transplantation Society
ISSN: 1399-3062
Titre abrégé: Transpl Infect Dis
Pays: Denmark
ID NLM: 100883688
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
revised:
03
12
2020
received:
01
11
2020
accepted:
13
12
2020
pubmed:
23
12
2020
medline:
3
8
2021
entrez:
22
12
2020
Statut:
ppublish
Résumé
EBV-positive mucocutaneous ulcer (EBV-MCU) is a rare EBV-positive B-cell lymphoproliferative disorder occurring in immunocompromised patients such as patients with solid organ or hematopoietic stem cells transplantation. EBV-MCU often consists of an isolated and circumscribed cutaneous or mucosal ulcerative lesion with a self-limited growth potential and a high regression rate upon immunosuppressive treatment withdrawal or rituximab therapy. Nevertheless, the pathophysiology of this latent infection leading to clonal lymphoproliferation is not well established. We report here two cases of EBV-MCU in kidney transplant recipients with a dissociated immune response to EBV with the absence of EBV-related antibodies and a positive T-cell response to EBV suggesting a potential specific oncogenic mechanism in this lymphoproliferative disorder.
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13552Informations de copyright
© 2020 Wiley Periodicals LLC.
Références
Dharnidharka VR, Webster AC, Martinez OM, Preiksaitis JK, Leblond V, Choquet S. Post-transplant lymphoproliferative disorders. Nat Rev Dis Prim. 2016;15088: https://doi.org/10.1038/nrdp.2015.88
Swerdlow SH, Campo E, Pileri SA, et al. The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood. 2016;127(20):2375-2391. https://doi.org/10.1182/blood-2016-01-643569.The
Hart M, Thakral B, Yohe S, et al. EBV-positive mucocutaneous ulcer in organ transplant recipients: a localized indolent posttransplant lymphoproliferative disorder. Am J Surg Pathol. 2014;38(11):1522-1529. https://doi.org/10.1097/PAS.0000000000000282
Dojcinov SD, Venkataraman G, Raffeld M, Pittaluga S, Jaffe ES. EBV Positive Mucocutaneous Ulcer-A Study of 26 Cases Associated With Various Sources of Immunosuppression. Am J Surg Pathol. 2010;34(3):405-417. https://doi.org/10.1097/PAS.0b013e3181cf8622
Babcock GJ, Decker LL, Volk M, Thorley-Lawson DA. EBV persistence in memory B cells in vivo. Immunity. 1998;9(3):395-404. https://doi.org/10.1016/S1074-7613(00)80622-6
Leblond V, Dhedin N, Bruneel M-F, et al. Identification of prognostic factors in 61 patients with posttransplantation lymphoproliferative disorders. J Clin Oncol. 2001;19(3):772-778. https://doi.org/10.1200/JCO.2001.19.3.772
Makis W, Deschenes J. Cerebral and pulmonary lymphomatoid granulomatosis and EBV positive oesophageal ulcer in an immunosuppressed renal transplant patient staged and followed with serial MRI and 18 F-FDG PET/CT after rituximab therapy. BJR|case reports. 2016;2(3):20150503. https://doi.org/10.1259/bjrcr.20150503
Gali V, Bleeker JS, Lynch D. Epstein-Barr Virus Positive Mucocutaneous Ulcer: A Case Report. S D Med. 2018;71(6):252-255. https://pubmed.ncbi.nlm.nih.gov/30005148/. Accessed December 3, 2020
Patek B, Strahotin C. Early Onset Post-transplant Lymphoproliferative Disorder Presenting with Diarrhea Post-orthotopic Liver Transplant Treated Successfully with Single Rituximab Agent. Cureus. 2019;11(11):1-7. https://doi.org/10.7759/cureus.6200
Onafowokan O, Rodgers W, Gruber E. Epstein-Barr virus-positive mucocutaneous ulcer of the oral cavity in a patient who had had a renal transplant. Br J Oral Maxillofac Surg. 2018;56(7):626-628. https://doi.org/10.1016/j.bjoms.2018.06.003
Isnard P, Kula T, Avettand Fenoel V, et al. Temporal virus serological profiling of kidney graft recipients using VirScan. Proc Natl Acad Sci U S A. 2019;166(22):10899-10904. https://doi.org/10.1073/pnas.1821166116
Davis JE, Sherritt MA, Bharadwaj M, et al. Determining virological, serological and immunological parameters of EBV infection in the development of PTLD. Int Immunol. 2004;16(7):983-989. https://doi.org/10.1093/intimm/dxh099