Source and Composition in Amino Acid of Dietary Proteins in the Primary Prevention and Treatment of CKD.
amino-acids
chronic kidney disease
low-protein diet
plant-based diet
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
19 Dec 2020
19 Dec 2020
Historique:
received:
03
11
2020
revised:
14
12
2020
accepted:
15
12
2020
entrez:
23
12
2020
pubmed:
24
12
2020
medline:
20
4
2021
Statut:
epublish
Résumé
Nutrition is a cornerstone in the management of chronic kidney disease (CKD). To limit urea generation and accumulation, a global reduction in protein intake is routinely proposed. However, recent evidence has accumulated on the benefits of plant-based diets and plant-derived proteins without a clear understanding of underlying mechanisms. Particularly the roles of some amino acids (AAs) appear to be either deleterious or beneficial on the progression of CKD and its complications. This review outlines recent data on the role of a low protein intake, the plant nature of proteins, and some specific AAs actions on kidney function and metabolic disorders. We will focus on renal hemodynamics, intestinal microbiota, and the production of uremic toxins. Overall, these mechanistic effects are still poorly understood but deserve special attention to understand why low-protein diets provide clinical benefits and to find potential new therapeutic targets in CKD.
Identifiants
pubmed: 33352729
pii: nu12123892
doi: 10.3390/nu12123892
pmc: PMC7766732
pii:
doi:
Substances chimiques
Amino Acids
0
Plant Proteins, Dietary
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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