Role of CD146 (MCAM) in Physiological and Pathological Angiogenesis-Contribution of New Antibodies for Therapy.
CD146
angiogenesis
cancer
endothelial cell
inflammation
monoclonal antibodies
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
19 Dec 2020
19 Dec 2020
Historique:
received:
30
10
2020
revised:
14
12
2020
accepted:
16
12
2020
entrez:
23
12
2020
pubmed:
24
12
2020
medline:
24
12
2020
Statut:
epublish
Résumé
The fundamental role of cell adhesion molecules in mediating various biological processes as angiogenesis has been well-documented. CD146, an adhesion molecule of the immunoglobulin superfamily, and its soluble form, constitute major players in both physiological and pathological angiogenesis. A growing body of evidence shows soluble CD146 to be significantly elevated in the serum or interstitial fluid of patients with pathologies related to deregulated angiogenesis, as autoimmune diseases, obstetric and ocular pathologies, and cancers. To block the undesirable effects of this molecule, therapeutic antibodies have been developed. Herein, we review the multifaceted functions of CD146 in physiological and pathological angiogenesis and summarize the interest of using monoclonal antibodies for therapeutic purposes.
Identifiants
pubmed: 33352759
pii: biomedicines8120633
doi: 10.3390/biomedicines8120633
pmc: PMC7767164
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
Clin Cancer Res. 2003 Dec 15;9(17):6560-6
pubmed: 14695161
Lab Invest. 2004 Feb;84(2):221-8
pubmed: 14688802
Matrix Biol. 2014 Sep;38:69-83
pubmed: 24951930
Curr Top Microbiol Immunol. 2010;345:105-20
pubmed: 20517715
Circ Res. 2010 Jul 9;107(1):66-75
pubmed: 20448216
J Hepatol. 2009 Mar;50(3):604-20
pubmed: 19157625
Blood. 2010 May 6;115(18):3843-51
pubmed: 20185588
Sci Rep. 2019 Nov 27;9(1):17721
pubmed: 31776424
Anticancer Res. 2012 Mar;32(3):861-4
pubmed: 22399604
Blood. 2005 Oct 15;106(8):2923-4
pubmed: 16204154
Nat Commun. 2017 Jun 07;8:15279
pubmed: 28589943
J Cell Sci. 2001 May;114(Pt 10):1847-59
pubmed: 11329371
J Cell Commun Signal. 2019 Sep;13(3):291-301
pubmed: 30903604
Oncotarget. 2017 Nov 28;8(68):112283-112296
pubmed: 29348825
Biochim Biophys Acta. 2007 Apr;1773(4):513-20
pubmed: 17320204
J Cell Physiol. 2008 Jun;215(3):621-6
pubmed: 18288634
Prostate. 2008 Mar 1;68(4):418-26
pubmed: 18196513
Oncol Lett. 2013 Apr;5(4):1189-1194
pubmed: 23599761
Circ Res. 2012 Apr 27;110(9):1252-64
pubmed: 22539758
Nat Commun. 2013;4:2803
pubmed: 24335906
Kidney Int. 2016 Aug;90(2):311-324
pubmed: 27165833
Angiogenesis. 2013 Apr;16(2):329-42
pubmed: 23108590
Int J Cancer. 2006 Oct 15;119(8):1920-6
pubmed: 16804906
Proc Natl Acad Sci U S A. 2006 Oct 24;103(43):15975-80
pubmed: 17043243
Redox Biol. 2017 Aug;12:18-34
pubmed: 28212521
J Biol Chem. 2013 Jan 25;288(4):2571-9
pubmed: 23223580
J Exp Clin Cancer Res. 2016 Feb 29;35:38
pubmed: 26928402
Thromb Haemost. 2005 Dec;94(6):1280-4
pubmed: 16411406
J Biol Chem. 1998 Oct 9;273(41):26852-6
pubmed: 9756930
Blood. 2001 Dec 15;98(13):3677-84
pubmed: 11739172
Gene. 2004 Mar 3;327(2):201-13
pubmed: 14980717
PLoS One. 2012;7(8):e43752
pubmed: 22952755
Cell Physiol Biochem. 2018;48(1):63-74
pubmed: 30001528
PLoS One. 2017 Mar 14;12(3):e0173724
pubmed: 28291830
PLoS One. 2012;7(7):e40443
pubmed: 22792325
Sci Rep. 2017 Aug 7;7(1):7442
pubmed: 28785085
Proc Natl Acad Sci U S A. 1989 Dec;86(24):9891-5
pubmed: 2602381
Protein Cell. 2018 Aug;9(8):743-747
pubmed: 29039032
Cell Rep. 2019 Oct 29;29(5):1311-1322.e5
pubmed: 31665642
J Thorac Oncol. 2016 Jun;11(6):789-800
pubmed: 26845192
Indian J Med Res. 2018 Jun;147(6):552-559
pubmed: 30168486
Cell Res. 2015 Mar;25(3):275-87
pubmed: 25656845
Cancer Res. 2010 Aug 1;70(15):6216-24
pubmed: 20647324
Genes Cells. 2010 Nov;15(11):1099-110
pubmed: 20977546
Cardiovasc Res. 2016 Aug 1;111(3):240-51
pubmed: 27170199
J Biol Chem. 2017 May 19;292(20):8381-8389
pubmed: 28364041
Cytometry B Clin Cytom. 2010 Mar;78(2):88-95
pubmed: 19834966
Free Radic Biol Med. 2010 Jul 15;49(2):227-36
pubmed: 20403426
Tumour Biol. 2012 Feb;33(1):173-82
pubmed: 22076922
Oncotarget. 2016 Jun 28;7(26):40704-40718
pubmed: 27302922
Proc Natl Acad Sci U S A. 2017 Sep 5;114(36):E7622-E7631
pubmed: 28827364
Cancer Res. 2017 Aug 15;77(16):4414-4425
pubmed: 28646020
J Lab Clin Med. 2002 Nov;140(5):320-8
pubmed: 12434133
Proc Natl Acad Sci U S A. 2012 Jan 24;109(4):1127-32
pubmed: 22210108
Theranostics. 2018 Mar 28;8(9):2447-2458
pubmed: 29721091
Commun Biol. 2020 Jan 21;3(1):37
pubmed: 31965050
Arterioscler Thromb Vasc Biol. 2009 May;29(5):746-53
pubmed: 19229070
Reproduction. 2020 Jul;160(1):39-51
pubmed: 32272449
Theranostics. 2020 Jan 1;10(1):231-246
pubmed: 31903117
Signal Transduct Target Ther. 2020 Aug 11;5(1):148
pubmed: 32782280
J Allergy Clin Immunol. 2017 Nov;140(5):1448-1451.e6
pubmed: 28606586
J Invest Dermatol. 2015 Jan;135(1):311-314
pubmed: 25058615
Br J Cancer. 2014 Mar 4;110(5):1236-43
pubmed: 24473396
Cancer Res. 2002 Sep 1;62(17):5106-14
pubmed: 12208768
Trends Immunol. 2013 Mar;34(3):129-36
pubmed: 23036432
Circ Res. 2007 Mar 30;100(6):782-94
pubmed: 17395884
Reprod Biol Endocrinol. 2005 Oct 20;3:56
pubmed: 16236179
Int Urol Nephrol. 2012 Dec;44(6):1663-9
pubmed: 22826148
Int J Ophthalmol. 2019 Mar 18;12(3):457-463
pubmed: 30918816
PLoS One. 2014 Nov 26;9(11):e113419
pubmed: 25427002
Cancer Lett. 2017 Feb 1;386:65-76
pubmed: 27838413
Ann Maxillofac Surg. 2011 Jul;1(2):150-4
pubmed: 23482819
Int J Mol Sci. 2012;13(5):6399-406
pubmed: 22754372
Nature. 1997 Apr 17;386(6626):671-4
pubmed: 9109485
Int J Rheum Dis. 2013 Aug;16(4):448-54
pubmed: 23992267
Sci Rep. 2017 Jul 10;7(1):4946
pubmed: 28694515
Blood. 2003 Jul 1;102(1):184-91
pubmed: 12609848
Annu Rev Vis Sci. 2015 Nov 24;1:155-184
pubmed: 28532369
Sci Rep. 2017 Jun 26;7(1):4223
pubmed: 28652617
Oncogene. 2012 Jan 19;31(3):306-21
pubmed: 21725352
Med Oncol. 2012 Dec;29(4):2998-3002
pubmed: 22271434
Protein Cell. 2018 Dec;9(12):1050-1054
pubmed: 29671201
FEBS Lett. 2006 Jun 26;580(15):3649-56
pubmed: 16756976
Nature. 2005 Dec 15;438(7070):960-6
pubmed: 16355161
Protein Cell. 2014 Jun;5(6):445-56
pubmed: 24756564
Cancer Lett. 2013 Apr 28;330(2):150-62
pubmed: 23266426
Breast Cancer Res. 2009;11(1):R1
pubmed: 19123925
Biomed Res Int. 2014;2014:756078
pubmed: 24949467
J Invest Dermatol. 2000 Aug;115(2):219-24
pubmed: 10951239
Int J Cancer. 2020 Sep 15;147(6):1666-1679
pubmed: 32022257
Blood. 2012 Sep 13;120(11):2330-9
pubmed: 22718841
BMC Syst Biol. 2015 Sep 04;9:55
pubmed: 26341082
Fertil Steril. 1992 Sep;58(3):537-42
pubmed: 1521649
J Biol Chem. 2013 Mar 29;288(13):8991-9000
pubmed: 23389031
Brain. 2009 Dec;132(Pt 12):3329-41
pubmed: 19933767
Tumour Biol. 2012 Oct;33(5):1619-28
pubmed: 22610942
Oncogene. 2016 Oct 20;35(42):5489-5500
pubmed: 27065325
Dev Dyn. 2005 Jan;232(1):232-44
pubmed: 15580611