Evaluation of the In Vitro Cytotoxic Activity of Caffeic Acid Derivatives and Liposomal Formulation against Pancreatic Cancer Cell Lines.
anticancer
caffeic acid
caffeic acid derivatives
cytotoxicity
liposomes
pancreatic cancer
pancreatic ductal adenocarcinoma
Journal
Materials (Basel, Switzerland)
ISSN: 1996-1944
Titre abrégé: Materials (Basel)
Pays: Switzerland
ID NLM: 101555929
Informations de publication
Date de publication:
19 Dec 2020
19 Dec 2020
Historique:
received:
20
11
2020
revised:
13
12
2020
accepted:
16
12
2020
entrez:
23
12
2020
pubmed:
24
12
2020
medline:
24
12
2020
Statut:
epublish
Résumé
Pancreatic cancer belongs to the most aggressive group of cancers, with very poor prognosis. Therefore, there is an important need to find more potent drugs that could deliver an improved therapeutic approach. In the current study we searched for selective and effective caffeic acid derivatives. For this purpose, we analyzed twelve compounds and evaluated their in vitro cytotoxic activity against two human pancreatic cancer cell lines, along with a control, normal fibroblast cell line, by the classic MTT assay. Six out of twelve tested caffeic acid derivatives showed a desirable effect. To improve the therapeutic efficacy of such active compounds, we developed a formulation where caffeic acid derivative (7) was encapsulated into liposomes composed of soybean phosphatidylcholine and DSPE-PEG
Identifiants
pubmed: 33352809
pii: ma13245813
doi: 10.3390/ma13245813
pmc: PMC7766656
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Łukasiewicz Research Network - Industrial Chemistry Institute
ID : 841333
Organisme : Polish Ministry of Science and Higher Education for the Faculty of Biotechnology of University of Wroclaw
ID : 841333
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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