Tavarua Deoxyriboside A and Jasplakinolide as Potential Neuroprotective Agents: Effects on Cellular Models of Oxidative Stress and Neuroinflammation.
Nrf2
Oxidative stress
gp91
jasplakinolide
neuroinflammation
tavarua deoxyriboside A
Journal
ACS chemical neuroscience
ISSN: 1948-7193
Titre abrégé: ACS Chem Neurosci
Pays: United States
ID NLM: 101525337
Informations de publication
Date de publication:
06 01 2021
06 01 2021
Historique:
pubmed:
24
12
2020
medline:
22
6
2021
entrez:
23
12
2020
Statut:
ppublish
Résumé
The oceans harbor a great reservoir of molecules with unknown bioactivities, which could be useful for the treatment of illnesses that nowadays have no cure, such as neurodegenerative diseases. In this work, we evaluated the neuroprotective potential of the marine Fijian compounds tavarua deoxyriboside A and jasplakinolide against oxidative stress and neuroinflammation, crucial mechanisms in neurodegeneration. Both metabolites protected SH-SY5Y human neuroblastoma cells from H
Identifiants
pubmed: 33353294
doi: 10.1021/acschemneuro.0c00626
doi:
Substances chimiques
Depsipeptides
0
Lipopolysaccharides
0
Neuroprotective Agents
0
jasplakinolide
102396-24-7
Hydrogen Peroxide
BBX060AN9V
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM