Systemic Inflammation Scores Predict the Activity of First-Line Chemotherapy in Patients with Metastatic Pancreatic Adenocarcinoma.
Metastatic pancreatic cancer
derived neutrophil-to-lymphocyte ratio
systemic inflammation response
trilinear peripheric blood cell score
Journal
Cancer investigation
ISSN: 1532-4192
Titre abrégé: Cancer Invest
Pays: England
ID NLM: 8307154
Informations de publication
Date de publication:
Jan 2021
Jan 2021
Historique:
pubmed:
24
12
2020
medline:
14
1
2021
entrez:
23
12
2020
Statut:
ppublish
Résumé
Systemic inflammation response (SIR)-related variables are controversial as predictive variables. Patients with metastatic pancreatic adenocarcinoma (mPDAC) receiving chemotherapy were identified, three SIR-related variables and the relationships between each of them with overall survival (OS) were analysed. Of 129 patients receiving chemotherapy, 97 had metastases. A significant relationship between SIR and OS has been documented. Each of the SIR-related variables retained its independent prognostic role after multivariate analysis, whereas tri-linear peripheric blood-cell score (TRIS) appeared as the most reliable predictive parameter. Among patients with mPDAC receiving chemotherapy, SIR is prognostic and could predict the effectiveness of chemotherapy.
Sections du résumé
BACKGROUND
BACKGROUND
Systemic inflammation response (SIR)-related variables are controversial as predictive variables.
METHODS
METHODS
Patients with metastatic pancreatic adenocarcinoma (mPDAC) receiving chemotherapy were identified, three SIR-related variables and the relationships between each of them with overall survival (OS) were analysed.
RESULTS
RESULTS
Of 129 patients receiving chemotherapy, 97 had metastases. A significant relationship between SIR and OS has been documented. Each of the SIR-related variables retained its independent prognostic role after multivariate analysis, whereas tri-linear peripheric blood-cell score (TRIS) appeared as the most reliable predictive parameter.
CONCLUSIONS
CONCLUSIONS
Among patients with mPDAC receiving chemotherapy, SIR is prognostic and could predict the effectiveness of chemotherapy.
Identifiants
pubmed: 33353411
doi: 10.1080/07357907.2020.1863419
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM