Assessment of platelet biology in equine patients with systemic inflammatory response syndrome.
horses
impedance aggregometry
multiplate analyzer
platelet function
Journal
Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
ISSN: 1943-4936
Titre abrégé: J Vet Diagn Invest
Pays: United States
ID NLM: 9011490
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
pubmed:
24
12
2020
medline:
7
5
2021
entrez:
23
12
2020
Statut:
ppublish
Résumé
In addition to maintaining hemostasis, platelets have an important role in modulating innate and adaptive immune responses. A low platelet count has been found to be a negative prognostic factor for survival in humans and horses with critical illnesses, such as sepsis or systemic inflammatory response syndrome (SIRS). Decreased platelet aggregation, caused by in vivo activation, has been found in human patients with severe sepsis. In our prospective controlled study, we assessed platelet biology in blood samples from 20 equine SIRS cases and 120 healthy control horses. Platelet variables such as platelet count, large platelet count, clumps, plateletcrit, mean platelet volume, and mean platelet component concentration were analyzed by laser flow cytometry (Advia 2120) from K
Identifiants
pubmed: 33353486
doi: 10.1177/1040638720983791
pmc: PMC7944423
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
300-307Références
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