Should Denosumab or Radical Surgery Be Recommended for a Spinal Giant Cell Tumour in a Fertile Female?
giant cell tumour of bone
spinal tumor
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
17 Nov 2020
17 Nov 2020
Historique:
entrez:
23
12
2020
pubmed:
24
12
2020
medline:
24
12
2020
Statut:
epublish
Résumé
Giant cell tumour (GCT) of the spine is a benign aggressive tumour with high recurrence rates. Patients can be asymptomatic due to the slow growth rate and present with localized pain or neurological dysfunction. Current management strategies include intralesional curettage, total en-bloc resection (TER) and denosumab therapy. Treatment strategies can be particularly challenging in women of childbearing age who wish to conceive, as the risks of tumour recurrence need to be balanced against the fetal complications associated with adjuvant denosumab therapy. This case report discusses the management options and controversies for women of childbearing age with GCT of the thoracic spine. Clinicians need to be aware of the complications associated with TER and denosumab treatment when managing GCTs of the spine in young females.
Identifiants
pubmed: 33354470
doi: 10.7759/cureus.11526
pmc: PMC7746321
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e11526Informations de copyright
Copyright © 2020, Rajgor et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Radiographics. 2013 Jan-Feb;33(1):197-211
pubmed: 23322837
Clin Sarcoma Res. 2016 Sep 14;6(1):15
pubmed: 27651889
Chin Med J (Engl). 2017 Jul 5;130(13):1557-1563
pubmed: 28639571
Arch Bone Jt Surg. 2018 Jul;6(4):260-268
pubmed: 30175172
J Int Med Res. 2012;40(2):415-25
pubmed: 22613402
Lancet Oncol. 2013 Aug;14(9):901-8
pubmed: 23867211
Radiol Med. 2014 Sep;119(9):681-93
pubmed: 24531890
Acta Orthop. 2018 Oct;89(5):570-574
pubmed: 29987945
Bone. 2014 Jul;64:314-25
pubmed: 24727159
World J Surg Oncol. 2018 Sep 19;16(1):191
pubmed: 30231890
Acta Oncol. 2014 Sep;53(9):1173-9
pubmed: 24834795
World Neurosurg. 2017 Feb;98:217-229
pubmed: 27794510
Orthop Clin North Am. 2006 Jan;37(1):35-51
pubmed: 16311110
Eur Spine J. 2010 Feb;19(2):231-41
pubmed: 19690899
Eur Spine J. 2010 Jul;19(7):1189-94
pubmed: 20076978
Spine (Phila Pa 1976). 2015 Feb 1;40(3):E146-53
pubmed: 25423305
Ann Surg Oncol. 2015 Sep;22(9):2860-8
pubmed: 26033180