Clinical, radiologic, and genetic characteristics of histone H3 K27M-mutant diffuse midline gliomas in adults.

H3 K27M adult diffuse midline glioma genetics survival

Journal

Neuro-oncology advances
ISSN: 2632-2498
Titre abrégé: Neurooncol Adv
Pays: England
ID NLM: 101755003

Informations de publication

Date de publication:
Historique:
entrez: 23 12 2020
pubmed: 24 12 2020
medline: 24 12 2020
Statut: epublish

Résumé

"Diffuse midline glioma (DMG), H3 K27M-mutant" is a new tumor entity established in the 2016 WHO classification of Tumors of the Central Nervous System that comprises a set of diffuse gliomas arising in midline structures and is molecularly defined by a K27M mutation in genes encoding the histone 3 variants H3.3 or H3.1. While this tumor entity is associated with poor prognosis in children, clinical experience in adults remains limited. Patient demographics, radiologic and pathologic characteristics, treatment course, progression, and patient survival were collected for 60 adult patients with DMG, H3 K27M-mutant. A subset of tumors also underwent next-generation sequencing. Analysis of progression-free survival and overall survival was conducted using Kaplan-Meier modeling, and univariate and multivariate analysis. Median patient age was 32 years (range 18-71 years). Tumors were centered in the thalamus ( Together, these findings indicate that H3 K27M-mutant DMG represents a heterogeneous disease with regard to outcomes, sites of origin, and molecular pathogenesis in adults versus children.

Sections du résumé

BACKGROUND BACKGROUND
"Diffuse midline glioma (DMG), H3 K27M-mutant" is a new tumor entity established in the 2016 WHO classification of Tumors of the Central Nervous System that comprises a set of diffuse gliomas arising in midline structures and is molecularly defined by a K27M mutation in genes encoding the histone 3 variants H3.3 or H3.1. While this tumor entity is associated with poor prognosis in children, clinical experience in adults remains limited.
METHODS METHODS
Patient demographics, radiologic and pathologic characteristics, treatment course, progression, and patient survival were collected for 60 adult patients with DMG, H3 K27M-mutant. A subset of tumors also underwent next-generation sequencing. Analysis of progression-free survival and overall survival was conducted using Kaplan-Meier modeling, and univariate and multivariate analysis.
RESULTS RESULTS
Median patient age was 32 years (range 18-71 years). Tumors were centered in the thalamus (
CONCLUSIONS CONCLUSIONS
Together, these findings indicate that H3 K27M-mutant DMG represents a heterogeneous disease with regard to outcomes, sites of origin, and molecular pathogenesis in adults versus children.

Identifiants

pubmed: 33354667
doi: 10.1093/noajnl/vdaa142
pii: vdaa142
pmc: PMC7739048
doi:

Types de publication

Journal Article

Langues

eng

Pagination

vdaa142

Subventions

Organisme : NIH HHS
ID : DP5 OD021403
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA097257
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA227136
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS079697
Pays : United States

Informations de copyright

© The Author(s) 2020. Published by Oxford University Press, the Society for Neuro-Oncology and the European Association of Neuro-Oncology.

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Auteurs

Jessica D Schulte (JD)

Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
Department of Neurology, University of California, San Francisco, San Francisco, California, USA.

Robin A Buerki (RA)

Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.

Sarah Lapointe (S)

Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.

Annette M Molinaro (AM)

Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.

Yalan Zhang (Y)

Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.

Javier E Villanueva-Meyer (JE)

Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA.

Arie Perry (A)

Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
Department of Pathology, University of California, San Francisco, San Francisco, California, USA.

Joanna J Phillips (JJ)

Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
Department of Pathology, University of California, San Francisco, San Francisco, California, USA.

Tarik Tihan (T)

Department of Pathology, University of California, San Francisco, San Francisco, California, USA.

Andrew W Bollen (AW)

Department of Pathology, University of California, San Francisco, San Francisco, California, USA.

Melike Pekmezci (M)

Department of Pathology, University of California, San Francisco, San Francisco, California, USA.

Nicholas Butowski (N)

Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.

Nancy Ann Oberheim Bush (NA)

Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
Department of Neurology, University of California, San Francisco, San Francisco, California, USA.

Jennie W Taylor (JW)

Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
Department of Neurology, University of California, San Francisco, San Francisco, California, USA.

Susan M Chang (SM)

Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.

Philip Theodosopoulos (P)

Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.

Manish K Aghi (MK)

Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.

Shawn L Hervey-Jumper (SL)

Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.

Mitchel S Berger (MS)

Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.

David A Solomon (DA)

Department of Pathology, University of California, San Francisco, San Francisco, California, USA.

Jennifer L Clarke (JL)

Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
Department of Neurology, University of California, San Francisco, San Francisco, California, USA.

Classifications MeSH