COVID-19-associated collapsing glomerulopathy: a report of two cases and literature review.
APOL1
COVID-19
COVID-associated nephropathy
acute kidney injury
collapsing glomerulopathy
nephrotic syndrome
Journal
Internal medicine journal
ISSN: 1445-5994
Titre abrégé: Intern Med J
Pays: Australia
ID NLM: 101092952
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
12
05
2020
revised:
13
07
2020
accepted:
16
08
2020
entrez:
23
12
2020
pubmed:
24
12
2020
medline:
21
1
2021
Statut:
ppublish
Résumé
Nephrotic range proteinuria has been reported during the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease (COVID-19). However, the pathological mechanisms underlying this manifestation are unknown. In this article, we present two cases of collapsing glomerulopathy (CG) associated with acute tubular necrosis during the course of COVID-19, and review the literature for similar reports. In our two cases, as in the 14 cases reported so far, the patients were of African ancestry. The 14 patients assessed had an APOL1 high-risk genotype. At the end of the reported period, two patients had died and five patients were still requiring dialysis. The 16 cases detailed in the present report strongly argue in favour of a causal link between SARS-CoV-2 infection and the occurrence of CG in patients homozygous for APOL1 high-risk genotype for which the term COVID-associated nephropathy (COVIDAN) can be put forward.
Types de publication
Case Reports
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1551-1558Informations de copyright
© 2020 Royal Australasian College of Physicians.
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