Cellular birthdate predicts laminar and regional cholinergic projection topography in the forebrain.
basal forebrain
cholinergic
cortex
developmental biology
mouse
neuroscience
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
23 12 2020
23 12 2020
Historique:
received:
18
09
2020
accepted:
13
12
2020
entrez:
23
12
2020
pubmed:
24
12
2020
medline:
19
3
2021
Statut:
epublish
Résumé
The basal forebrain cholinergic system projects broadly throughout the cortex and constitutes a critical source of neuromodulation for arousal and attention. Traditionally, this system was thought to function diffusely. However, recent studies have revealed a high degree of spatiotemporal specificity in cholinergic signaling. How the organization of cholinergic afferents confers this level of precision remains unknown. Here, using intersectional genetic fate mapping, we demonstrate that cholinergic fibers within the mouse cortex exhibit remarkable laminar and regional specificity and that this is organized in accordance with cellular birthdate. Strikingly, birthdated cholinergic projections within the cortex follow an inside-out pattern of innervation. While early born cholinergic populations target deep layers, late born ones innervate superficial laminae. We also find that birthdate predicts cholinergic innervation patterns within the amygdala, hippocampus, and prefrontal cortex. Our work reveals previously unappreciated specificity within the cholinergic system and the developmental logic by which these circuits are assembled.
Identifiants
pubmed: 33355093
doi: 10.7554/eLife.63249
pii: 63249
pmc: PMC7758062
doi:
pii:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NINDS NIH HHS
ID : P01 NS074972
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS110079
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS081297
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA016087
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH071679
Pays : United States
Organisme : Simons Foundation
ID : 566615
Pays : International
Organisme : NINDS NIH HHS
ID : F31 NS103398
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS107257
Pays : United States
Organisme : NIH HHS
ID : UG3MH120096
Pays : United States
Organisme : NIH HHS
ID : 5P01NS074972
Pays : United States
Informations de copyright
© 2020, Allaway et al.
Déclaration de conflit d'intérêts
KA, WM, RT, MS, JH, BR, RM, GF No competing interests declared
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