Clot accumulation at the tip of hemodialysis catheters in a large animal model.
Catheters
Techniques and procedures
biomaterials
dialysis
dialysis access
new devices
Journal
The journal of vascular access
ISSN: 1724-6032
Titre abrégé: J Vasc Access
Pays: United States
ID NLM: 100940729
Informations de publication
Date de publication:
Jan 2022
Jan 2022
Historique:
pubmed:
29
12
2020
medline:
9
3
2022
entrez:
28
12
2020
Statut:
ppublish
Résumé
The issue of side holes in the tips of the tunneled cuffed central venous catheters is complex and has been subject to longstanding debate. This study sought to compare the clotting potential of the side-hole-free Pristine hemodialysis catheter with that of a symmetric catheter with side holes. Both jugular veins of five goats were catheterized with the two different catheters. The catheters were left in place for 4 weeks and were flushed and locked with heparin thrice weekly. The aspirated intraluminal clot length was assessed visually prior to each flushing. In addition, the size and weight of the clot were recorded upon catheter extraction at the end of the 4-week follow-up. The mean intraluminal clot length observed during the entire study follow-up measured up to a mean of 0.66 cm in the GlidePath (95% CI, 0.14-1.18) and 0.19 cm in the Pristine hemodialysis catheter (95% CI, -0.33 to 0.71), the difference being statistically significant ( The Pristine hemodialysis catheter was largely superior to a standard side hole catheter in impeding clot formation, and, contrary to the side hole catheter, allowed for complete aspiration of the intraluminal clot.
Sections du résumé
BACKGROUND
BACKGROUND
The issue of side holes in the tips of the tunneled cuffed central venous catheters is complex and has been subject to longstanding debate. This study sought to compare the clotting potential of the side-hole-free Pristine hemodialysis catheter with that of a symmetric catheter with side holes.
METHODS
METHODS
Both jugular veins of five goats were catheterized with the two different catheters. The catheters were left in place for 4 weeks and were flushed and locked with heparin thrice weekly. The aspirated intraluminal clot length was assessed visually prior to each flushing. In addition, the size and weight of the clot were recorded upon catheter extraction at the end of the 4-week follow-up.
RESULTS
RESULTS
The mean intraluminal clot length observed during the entire study follow-up measured up to a mean of 0.66 cm in the GlidePath (95% CI, 0.14-1.18) and 0.19 cm in the Pristine hemodialysis catheter (95% CI, -0.33 to 0.71), the difference being statistically significant (
CONCLUSION
CONCLUSIONS
The Pristine hemodialysis catheter was largely superior to a standard side hole catheter in impeding clot formation, and, contrary to the side hole catheter, allowed for complete aspiration of the intraluminal clot.
Identifiants
pubmed: 33356813
doi: 10.1177/1129729820983617
pmc: PMC8899813
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
128-134Références
ASAIO J. 2003 Nov-Dec;49(6):713-5
pubmed: 14655740
Int J Artif Organs. 1985 Jul;8(4):195-200
pubmed: 4055095
Nephrol Dial Transplant. 2014 Apr;29(4):892-8
pubmed: 24235075
J Vasc Interv Radiol. 2015 Feb;26(2):252-9.e2
pubmed: 25645414
Am J Kidney Dis. 1993 Jul;22(1):24-9
pubmed: 8322789
Radiology. 2000 Apr;215(1):129-37
pubmed: 10751478
Eur J Vasc Endovasc Surg. 2018 Jun;55(6):757-818
pubmed: 29730128
Nephrologie. 2001;22(8):403-5
pubmed: 11810996
BMC Nephrol. 2018 Apr 2;19(1):76
pubmed: 29609535
Artif Organs. 2004 Jul;28(7):639-48
pubmed: 15209857
Ann Surg. 1985 Nov;202(5):653-8
pubmed: 4051612
Semin Dial. 2007 May-Jun;20(3):237-56
pubmed: 17555490
Surg Gynecol Obstet. 1973 Jul;137(1):43-7
pubmed: 4714316
Am J Kidney Dis. 2006 Jul;48 Suppl 1:S248-73
pubmed: 16813991
J Infect Dis. 1988 Oct;158(4):693-701
pubmed: 3171224
Nephrol Dial Transplant. 2007 May;22 Suppl 2:ii88-117
pubmed: 17507428
J Vasc Surg. 2002 Mar;35(3):603-10
pubmed: 11877717
J Vasc Interv Radiol. 2003 Sep;14(9 Pt 2):S433-42
pubmed: 14514859
Semin Dial. 2008 Nov-Dec;21(6):504-15
pubmed: 19000125
J Vasc Surg. 2019 Apr;69(4):1282-1292
pubmed: 30905366
Am J Kidney Dis. 2020 Apr;75(4 Suppl 2):S1-S164
pubmed: 32778223
ASAIO J. 2005 May-Jun;51(3):230-5
pubmed: 15968952
Nephrol Dial Transplant. 2014 Oct;29(10):1956-64
pubmed: 25061126
J Infect Dis. 1989 Nov;160(5):865-75
pubmed: 2809259
J Am Soc Nephrol. 2013 Feb;24(3):465-73
pubmed: 23431075
Kidney Int. 2002 Jul;62(1):282-9
pubmed: 12081590
J Vasc Access. 2001 Jan-Mar;2(1):8-16
pubmed: 17638251
BMC Nephrol. 2017 Feb 22;18(1):74
pubmed: 28222688