The potential role of Na-K-ATPase and its signaling in the development of anemia in chronic kidney disease.


Journal

American journal of physiology. Renal physiology
ISSN: 1522-1466
Titre abrégé: Am J Physiol Renal Physiol
Pays: United States
ID NLM: 100901990

Informations de publication

Date de publication:
01 02 2021
Historique:
pubmed: 29 12 2020
medline: 2 3 2021
entrez: 28 12 2020
Statut: ppublish

Résumé

Chronic kidney disease (CKD) is one of the most prominent diseases affecting our population today. According to the Factsheet published by Centers for Disease Control and Prevention (CDC), it effects approximately 15% of the total population in the United States in some way, shape, or form. Within the myriad of symptomatology associated with CKD, one of the most prevalent factors in terms of affecting quality of life is anemia. Anemia of CKD cannot be completely attributed to one mechanism or cause, but rather has a multifactorial origin in the pathophysiology of CKD. While briefly summarizing well-documented risk factors, this review, as a hypothesis, aims to explore the possible role of Na-K-ATPase and its signaling function [especially recent identified reactive oxygen species (ROS) amplification function] in the interwoven mechanisms of development of the anemia of CKD.

Identifiants

pubmed: 33356956
doi: 10.1152/ajprenal.00244.2020
pmc: PMC7948124
doi:

Substances chimiques

Sodium-Potassium-Exchanging ATPase EC 7.2.2.13

Types de publication

Journal Article Research Support, N.I.H., Extramural Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

F234-F242

Subventions

Organisme : NHLBI NIH HHS
ID : U01 HL071556
Pays : United States
Organisme : NIH HHS
ID : R15 1R15DK106666
Pays : United States
Organisme : NHLBI NIH HHS
ID : R15 HL150721
Pays : United States
Organisme : NIDDK NIH HHS
ID : R15 DK106666
Pays : United States
Organisme : NIH HHS
ID : RO1 HL071556
Pays : United States
Organisme : NIH HHS
ID : R15 HL150721
Pays : United States

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Auteurs

Kyle D Maxwell (KD)

Department of Biomsedical Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, West Virginia.

Justin Chuang (J)

Department of Biomsedical Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, West Virginia.

Muhammad Chaudhry (M)

Department of Biomsedical Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, West Virginia.

Ying Nie (Y)

Department of Biomsedical Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, West Virginia.

Fang Bai (F)

Department of Biomsedical Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, West Virginia.

Komal Sodhi (K)

Department of Biomsedical Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, West Virginia.
Department of Medicine, Joan C. Edwards School of Medicine, Marshall University, Huntington, West Virginia.

Jiang Liu (J)

Department of Biomsedical Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, West Virginia.

Joseph I Shapiro (JI)

Department of Medicine, Joan C. Edwards School of Medicine, Marshall University, Huntington, West Virginia.

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Classifications MeSH