[Ketogenic diet: a new nutritional strategy for cancer therapy?]
Le régime cétogène : une stratégie alimentaire efficace en complément des traitements contre le cancer ?
Warburg effect
cancer therapy
effet Warburg
ketogenic diet
mitochondria
mitochondrie
oxidative metabolism
phosphorylation oxydative
régime cétogène
thérapie anticancéreuse
Journal
Biologie aujourd'hui
ISSN: 2105-0686
Titre abrégé: Biol Aujourdhui
Pays: France
ID NLM: 101544020
Informations de publication
Date de publication:
2020
2020
Historique:
received:
07
09
2020
entrez:
28
12
2020
pubmed:
29
12
2020
medline:
7
10
2021
Statut:
ppublish
Résumé
Cancer is a disease that can appear in several tissues and that kills more than 150 000 people in France every year. Cancer cells have mutations in their genome that lead to changes in their metabolism, compared to healthy cells. They use mostly glycolysis as their energy source, but not fatty acid oxidation. Currently, treatments used against cancer are nonspecific and have many side effects. Thus it appears increasingly important to find new strategies against cancer cells progression while protecting surrounding healthy cells and decreasing side effects. Ketogenic diet, which is a low-sugar high-fat diet, could be an interesting candidate as it alters the energy machinery of the cell and keeps away its primary energy source (glucose). This diet is largely used to treat refractory epilepsy and begins to be studied in oncology as well. This article describes the scientific evidence of the beneficial effects of the ketogenic diet and aims at showing how this complementary treatment could be useful against several cancers. Le régime cétogène : une stratégie alimentaire efficace en complément des traitements contre le cancer ? Le cancer est une pathologie qui touche tout type de tissu et qui tue chaque année en France plus de 150 000 personnes. Les cellules cancéreuses présentent des modifications dans leur métabolisme par rapport aux cellules saines, puisqu’elles tirent leur énergie très majoritairement de la glycolyse anaérobie et non de la phosphorylation oxydative mitochondriale : on parle de l’effet Warburg. À l’heure actuelle, les traitements les plus utilisés pour soigner le cancer en routine sont des traitements dits non spécifiques qui présentent de nombreux effets secondaires, altérant la vie des patients. Il semble de plus en plus crucial de trouver de nouvelles stratégies pour lutter contre la progression des cellules cancéreuses. Le régime cétogène, pauvre en sucres et riche en lipides, est un candidat intéressant, puisqu’il affaiblit la machinerie énergétique de la cellule cancéreuse. Ce régime est déjà utilisé dans le cadre de la prise en charge de l’épilepsie réfractaire aux traitements classiques, et commence à être étudié en cancérologie également. Cet article, qui fait le point sur les preuves scientifiques des effets bénéfiques du régime cétogène, souligne son intérêt thérapeutique potentiel comme traitement complémentaire pour lutter contre certains cancers.
Autres résumés
Type: Publisher
(fre)
Le régime cétogène : une stratégie alimentaire efficace en complément des traitements contre le cancer ?
Identifiants
pubmed: 33357370
doi: 10.1051/jbio/2020014
pii: jbio200014
doi:
Types de publication
Journal Article
Langues
fre
Sous-ensembles de citation
IM
Pagination
115-123Informations de copyright
© Société de Biologie, 2020.
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