TREX2 Exonuclease Causes Spontaneous Mutations and Stress-Induced Replication Fork Defects in Cells Expressing RAD51
DNA damage tolerance
double-strand break repair
genomic instability
homologous recombination
replication fork maintenance
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
22 12 2020
22 12 2020
Historique:
received:
16
10
2019
revised:
23
04
2020
accepted:
01
12
2020
entrez:
28
12
2020
pubmed:
29
12
2020
medline:
22
12
2021
Statut:
ppublish
Résumé
DNA damage tolerance (DDT) and homologous recombination (HR) stabilize replication forks (RFs). RAD18/UBC13/three prime repair exonuclease 2 (TREX2)-mediated proliferating cell nuclear antigen (PCNA) ubiquitination is central to DDT, an error-prone lesion bypass pathway. RAD51 is the recombinase for HR. The RAD51 K133A mutation increased spontaneous mutations and stress-induced RF stalls and nascent strand degradation. Here, we report in RAD51
Identifiants
pubmed: 33357432
pii: S2211-1247(20)31532-1
doi: 10.1016/j.celrep.2020.108543
pmc: PMC7896812
mid: NIHMS1657609
pii:
doi:
Substances chimiques
Phosphoproteins
0
RAD51 protein, human
EC 2.7.7.-
Rad51 Recombinase
EC 2.7.7.-
Exodeoxyribonucleases
EC 3.1.-
TREX2 protein, human
EC 3.1.16.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
108543Subventions
Organisme : NIEHS NIH HHS
ID : R01 ES022054
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA188032
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG017242
Pays : United States
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : P30 CA013330
Pays : United States
Organisme : Wellcome Trust
ID : 206292/E/17/Z
Pays : United Kingdom
Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Interests The authors declare no competing interests.
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