Slowly conducting potentials in human sensory nerves.

Action Potentials Afferent Pathways Humans Neural Conduction Pain Thermosensing
A-delta fibers Intraepidermal stimulation Near nerve recording Sensory nerve conduction Single fiber action potentials Technique

Journal

Journal of neuroscience methods
ISSN: 1872-678X
Titre abrégé: J Neurosci Methods
Pays: Netherlands
ID NLM: 7905558

Informations de publication

Date de publication:
01 03 2021
Historique:
received: 08 11 2020
revised: 13 12 2020
accepted: 15 12 2020
pubmed: 29 12 2020
medline: 1 7 2021
entrez: 28 12 2020
Statut: ppublish

Résumé

In clinical practice, small myelinated sensory fibers, Aδ-fibers, conveying mainly pain and temperature sensations, cannot be examined with available nerve conduction study techniques. Currently, these fibers can only be examined with experimental or very specialized and not commonly available nerve conduction techniques, or only indirectly with cerebral evoked potentials. This study uses equipment and methods available in clinical neurophysiology laboratories to record from human sensory nerves ≥1000 averaged responses to focal, non-painful stimuli applied by a special electrode to epidermal nerves. The averaged responses to odd numbered stimuli are compared to the averaged responses to even numbered stimuli. An algorithm identifies potentials common in both averages. The 99 The algorithm identifies numerous negative and positive potentials as being different from controls at the 99th and 99.9 No existing methods. The stimulation, recording and data analysis methods used in this study can be applied in the clinical EMG laboratory to identify Aδ-fibers in human sensory nerves.

Sections du résumé

BACKGROUND
In clinical practice, small myelinated sensory fibers, Aδ-fibers, conveying mainly pain and temperature sensations, cannot be examined with available nerve conduction study techniques. Currently, these fibers can only be examined with experimental or very specialized and not commonly available nerve conduction techniques, or only indirectly with cerebral evoked potentials.
NEW METHOD
This study uses equipment and methods available in clinical neurophysiology laboratories to record from human sensory nerves ≥1000 averaged responses to focal, non-painful stimuli applied by a special electrode to epidermal nerves. The averaged responses to odd numbered stimuli are compared to the averaged responses to even numbered stimuli. An algorithm identifies potentials common in both averages. The 99
RESULTS
The algorithm identifies numerous negative and positive potentials as being different from controls at the 99th and 99.9
COMPARISON WITH EXISTING METHOD(S)
No existing methods.
CONCLUSIONS
The stimulation, recording and data analysis methods used in this study can be applied in the clinical EMG laboratory to identify Aδ-fibers in human sensory nerves.

Identifiants

DOI: 10.1016/j.jneumeth.2020.109045 PMID: 33358850
pubmed: 33358850
pii: S0165-0270(20)30468-4
doi: 10.1016/j.jneumeth.2020.109045
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

109045

Informations de copyright

Copyright © 2020 Elsevier B.V. All rights reserved.

Auteurs

W Raabe (W)

Department of Neurology, University of Minnesota, Minneapolis, MN, United States. Electronic address: raabe001@umn.edu.

D Walk (D)

Department of Neurology, University of Minnesota, Minneapolis, MN, United States.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Potentiels de membrane › Potentiels d'action › Slowly conducting potentials in human sensory nerves.
questionsmedicales.fr › Système nerveux › Voies nerveuses › Voies afférentes › Slowly conducting potentials in human sensory nerves.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Slowly conducting potentials in human sensory nerves.
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Conduction nerveuse › Slowly conducting potentials in human sensory nerves.
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Sensation › Douleur › Slowly conducting potentials in human sensory nerves.
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Sensation › Thermoception › Slowly conducting potentials in human sensory nerves.