Factors Associated with Asthma Severity in Children: Data from the French COBRAPed Cohort.
Phenotype
Preschool
School-age
Severe asthma
Journal
The journal of allergy and clinical immunology. In practice
ISSN: 2213-2201
Titre abrégé: J Allergy Clin Immunol Pract
Pays: United States
ID NLM: 101597220
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
received:
01
05
2020
revised:
30
11
2020
accepted:
09
12
2020
pubmed:
29
12
2020
medline:
25
5
2021
entrez:
28
12
2020
Statut:
ppublish
Résumé
Severe asthma (SA) in children is a complex, heterogeneous disease, associated with a considerable burden. However, factors influencing asthma severity are poorly described and may differ according to age. To determine whether factors associated with asthma severity differ between preschoolers with severe recurrent wheeze (SRW) and school-age children with SA. Data from the French multicenter prospective observational cohort of preschool (3-6 years) children with SRW and nonsevere recurrent wheeze (NSRW) and school-age (7-11 years) children with SA and nonsevere asthma (NSA) (Pediatric Cohort of Bronchial Obstruction and Asthma) were analyzed. A total of 131 preschool children (92 SRW and 49 NSRW) and 207 school-age children (92 SA and 115 NSA) were included. In both univariable and multivariable analysis, SRW was associated with second-hand smoke exposure (multivariable analysis: odds ratio [95% CI], 29.8 [3.57-3910]) and exposure to mold/dampness at home (multivariable analysis: odds ratio [95% CI], 4.22 [1.25-18.2]) compared with NSRW. At school-age, history of atopic dermatitis and food allergy was more frequent in children with SA than in those with NSA. Multivariable analysis confirmed that SA was associated with a history of food allergy (odds ratio [95% CI], 5.01 [2.23-11.9]). Our data suggest that factors influencing asthma severity may differ according to age. In preschool children with SRW, second-hand smoke and exposure to mold are predominant, whereas associated allergic disorders are mainly involved in SA at school-age.
Sections du résumé
BACKGROUND
Severe asthma (SA) in children is a complex, heterogeneous disease, associated with a considerable burden. However, factors influencing asthma severity are poorly described and may differ according to age.
OBJECTIVE
To determine whether factors associated with asthma severity differ between preschoolers with severe recurrent wheeze (SRW) and school-age children with SA.
METHODS
Data from the French multicenter prospective observational cohort of preschool (3-6 years) children with SRW and nonsevere recurrent wheeze (NSRW) and school-age (7-11 years) children with SA and nonsevere asthma (NSA) (Pediatric Cohort of Bronchial Obstruction and Asthma) were analyzed.
RESULTS
A total of 131 preschool children (92 SRW and 49 NSRW) and 207 school-age children (92 SA and 115 NSA) were included. In both univariable and multivariable analysis, SRW was associated with second-hand smoke exposure (multivariable analysis: odds ratio [95% CI], 29.8 [3.57-3910]) and exposure to mold/dampness at home (multivariable analysis: odds ratio [95% CI], 4.22 [1.25-18.2]) compared with NSRW. At school-age, history of atopic dermatitis and food allergy was more frequent in children with SA than in those with NSA. Multivariable analysis confirmed that SA was associated with a history of food allergy (odds ratio [95% CI], 5.01 [2.23-11.9]).
CONCLUSIONS
Our data suggest that factors influencing asthma severity may differ according to age. In preschool children with SRW, second-hand smoke and exposure to mold are predominant, whereas associated allergic disorders are mainly involved in SA at school-age.
Identifiants
pubmed: 33359443
pii: S2213-2198(20)31359-3
doi: 10.1016/j.jaip.2020.12.027
pii:
doi:
Banques de données
ClinicalTrials.gov
['NCT02114034']
Types de publication
Journal Article
Multicenter Study
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1969-1979Investigateurs
Rola Abou-Taam
(R)
Muriel Le Bourgeois
(M)
Alice Hadchouel-Duvergé
(A)
David Drummond
(D)
Christophe Delacourt
(C)
Marie-Alexandra Alyanakian
(MA)
Lucienne Chatennoud
(L)
Caroline Thumerelle
(C)
Clémence Mordacq
(C)
Irina Badiu-Decleyre
(I)
Cécile Bonnel
(C)
Laure Delbecque
(L)
Laurent Beghin
(L)
Graziella Mingardi
(G)
Caroline Tournegros
(C)
Léa Roditis
(L)
Stéphanie Wanin
(S)
Marie Noelle Lebras
(MN)
Stéphane Debelleix
(S)
Valérie Siao
(V)
Marine Servat
(M)
Guillaume Simon
(G)
Patricia El Boustany
(P)
Emmanuelle Bosdure
(E)
Julie Mazenq
(J)
Isabelle Cabon
(I)
Camille Ohlmann
(C)
Stéphanie Vrielynck
(S)
Virginie Jubin
(V)
Sylvie-Anne André Gomez
(SA)
Marie-Christine Werck Gallois
(MC)
Informations de copyright
Copyright © 2020 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.