Senescence: A program in the road to cell elimination and cancer.
Nuclear lamina
PML
Polyploidy
Progerin
Therapy induced senescence (TIS)
Journal
Seminars in cancer biology
ISSN: 1096-3650
Titre abrégé: Semin Cancer Biol
Pays: England
ID NLM: 9010218
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
received:
05
10
2020
revised:
13
12
2020
accepted:
20
12
2020
pubmed:
29
12
2020
medline:
14
4
2022
entrez:
28
12
2020
Statut:
ppublish
Résumé
Senescence is a tumor suppressor response that prevents the proliferation of mutated cells and alert the immune system for their elimination. However, this program is not perfect and with time additional genetic and epigenetic changes can impair tumor suppression and promote cancer progression both in cell autonomous and non-cell autonomous manners. A polyploid barrier is implemented in senescent cells to further prevent cell expansion but polyploid cells can generate highly malignant tumor cells via de-polyploidization. The nuclear lamina can act as an additional fail safe to prevent cancer in these cells and drugs able to stabilize the nuclear lamina may help to treat cancers by preventing senescence escape.
Identifiants
pubmed: 33359514
pii: S1044-579X(20)30277-7
doi: 10.1016/j.semcancer.2020.12.017
pii:
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
48-53Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.