Thiolated polymeric hydrogels for biomedical application: Cross-linking mechanisms.

Hydrogels Polyethylene Glycols Polymers Sulfhydryl Compounds Tissue Engineering
Cross-linking Diagnostic Drug delivery Hydrogels Regenerative medicine Thiolated polymers Thiomers Tissue engineering

Journal

Journal of controlled release : official journal of the Controlled Release Society
ISSN: 1873-4995
Titre abrégé: J Control Release
Pays: Netherlands
ID NLM: 8607908

Informations de publication

Date de publication:
10 02 2021
Historique:
received: 08 09 2020
revised: 18 12 2020
accepted: 19 12 2020
pubmed: 29 12 2020
medline: 8 7 2021
entrez: 28 12 2020
Statut: ppublish

Résumé

This review focuses on the synthesis of hydrogel networks using thiomers such as thiolated hyaluronic acid, chitosan, cyclodextrin, poly(ethylene glycol) and dextran that are cross-linked via their thiol substructures. Thiomers have been widely investigated as matrix of hydrogels due to the high reactivity of these sulfhydryl moieties. They are well known for their in situ gelling properties due to the formation of inter- and intra-chain disulfide bonds. Furthermore, as thiol groups on the polymeric backbone of thiomers cannot only react with each other but also with different other functional groups, several "click" methods such as thiol-ene/yne, Michael type addition and thiol-epoxy reactions have been developed within the last decades to fabricate thiomer hydrogels. These hydrogels are meanwhile used as scaffolds for tissue engineering, regenerative medicine, diagnostics and as matrix for drug and protein delivery.

Identifiants

DOI: 10.1016/j.jconrel.2020.12.037 PMID: 33359581
pubmed: 33359581
pii: S0168-3659(20)30761-6
doi: 10.1016/j.jconrel.2020.12.037
pii:
doi:

Substances chimiques

Hydrogels 0
Polymers 0
Sulfhydryl Compounds 0
Polyethylene Glycols 3WJQ0SDW1A

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

470-482

Informations de copyright

Copyright © 2020 The Author(s). Published by Elsevier B.V. All rights reserved.

Auteurs

Simona Summonte (S)

Thiomatrix Forschungs- und Beratungs GmbH, Research Center Innsbruck, Trientlgasse 65, 6020, Innsbruck, Austria.

Giuseppe Francesco Racaniello (GF)

Department of Pharmacy - Pharmaceutical Sciences, University of Bari "Aldo Moro", Orabona St. 4, 70125 Bari, Italy.

Angela Lopedota (A)

Department of Pharmacy - Pharmaceutical Sciences, University of Bari "Aldo Moro", Orabona St. 4, 70125 Bari, Italy.

Nunzio Denora (N)

Department of Pharmacy - Pharmaceutical Sciences, University of Bari "Aldo Moro", Orabona St. 4, 70125 Bari, Italy.

Andreas Bernkop-Schnürch (A)

Thiomatrix Forschungs- und Beratungs GmbH, Research Center Innsbruck, Trientlgasse 65, 6020, Innsbruck, Austria; Department of Pharmaceutical Technology, Institute of Pharmacy, University of Innsbruck, Innrain 80-82, 6020 Innsbruck, Austria. Electronic address: andreas.bernkop@uibk.ac.at.

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Classifications MeSH

questionsmedicales.fr › Préparations pharmaceutiques › Colloïdes › Gels › Hydrogels › Thiolated polymeric hydrogels for biomedical...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › Polyéthylène glycols › Thiolated polymeric hydrogels for biomedical...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › Thiolated polymeric hydrogels for biomedical...
questionsmedicales.fr › Composés chimiques organiques › Composés du soufre › Thiols › Thiolated polymeric hydrogels for biomedical...
questionsmedicales.fr › Technologie, industrie et agriculture › Ingénierie › Bioingénierie › Ingénierie cellulaire › Ingénierie tissulaire › Thiolated polymeric hydrogels for biomedical...