Mitochondria-targeted phenolic antioxidants induce ROS-protective pathways in primary human skin fibroblasts.
Glutathione
Mitochondrial morphology
Reactive oxygen species
Superoxide dismutase
Journal
Free radical biology & medicine
ISSN: 1873-4596
Titre abrégé: Free Radic Biol Med
Pays: United States
ID NLM: 8709159
Informations de publication
Date de publication:
01 02 2021
01 02 2021
Historique:
received:
29
10
2020
revised:
10
12
2020
accepted:
11
12
2020
pubmed:
29
12
2020
medline:
23
6
2021
entrez:
28
12
2020
Statut:
ppublish
Résumé
Phytochemical antioxidants like gallic and caffeic acid are constituents of the normal human diet that display beneficial health effects, potentially via activating stress response pathways. Using primary human skin fibroblasts (PHSFs) as a model, we here investigated whether such pathways were induced by novel mitochondria-targeted variants of gallic acid (AntiOxBEN
Identifiants
pubmed: 33359686
pii: S0891-5849(20)31686-5
doi: 10.1016/j.freeradbiomed.2020.12.023
pii:
doi:
Substances chimiques
Antioxidants
0
NF-E2-Related Factor 2
0
Reactive Oxygen Species
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
314-324Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.