A redox-mediated conformational change in NQO1 controls binding to microtubules and α-tubulin acetylation.

3T3-L1 Cells Acetylation Animals Humans Mice Microtubules / metabolism NAD(P)H Dehydrogenase (Quinone) / genetics Oxidation-Reduction Sirtuin 2 / metabolism Tubulin / metabolism
Acetylation Microtubules NQO1 Pyridine nucleotides SIRT2 α-Tubulin

Journal

Redox biology
ISSN: 2213-2317
Titre abrégé: Redox Biol
Pays: Netherlands
ID NLM: 101605639

Informations de publication

Date de publication:
02 2021
Historique:
received: 21 09 2020
revised: 30 11 2020
accepted: 01 12 2020
pubmed: 29 12 2020
medline: 22 6 2021
entrez: 28 12 2020
Statut: ppublish

Résumé

The localization of NQO1 near acetylated microtubules has led to the hypothesis that NQO1 may work in concert with the NAD

Identifiants

DOI: 10.1016/j.redox.2020.101840 PMID: 33360352 PMC: PMC7772575
pubmed: 33360352
pii: S2213-2317(20)31045-4
doi: 10.1016/j.redox.2020.101840
pmc: PMC7772575
pii:
doi:

Substances chimiques

Tubulin 0
NAD(P)H Dehydrogenase (Quinone) EC 1.6.5.2
NQO1 protein, human EC 1.6.5.2
Nqo1 protein, mouse EC 1.6.5.2
Sirtuin 2 EC 3.5.1.-

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

101840

Subventions

Organisme : NIDDK NIH HHS
ID : R01 DK109964
Pays : United States

Informations de copyright

Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.

Auteurs

David Siegel (D)

Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA. Electronic address: david.siegel@cuanschutz.edu.

Stephanie Bersie (S)

Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.

Peter Harris (P)

Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.

Andrea Di Francesco (A)

Experimental Gerontology Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, 21224, USA.

Michael Armstrong (M)

Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.

Nichole Reisdorph (N)

Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.

Michel Bernier (M)

Experimental Gerontology Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, 21224, USA.

Rafael de Cabo (R)

Experimental Gerontology Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, 21224, USA.

Kristofer Fritz (K)

Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.

David Ross (D)

Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.

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Classifications MeSH

questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Fibroblastes › Cellules 3T3 › Cellules Swiss 3T3 › Cellules 3T3-L1 › A redox-mediated conformational change in NQO1...
questionsmedicales.fr › Métabolisme › Acylation › Acétylation › A redox-mediated conformational change in NQO1...
questionsmedicales.fr › Eucaryotes › Animaux › A redox-mediated conformational change in NQO1...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A redox-mediated conformational change in NQO1...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › A redox-mediated conformational change in NQO1...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Cytosquelette › Microtubules › A redox-mediated conformational change in NQO1...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › NADH, NADPH oxidoreductases › Quinone reductases › NADPH dehydrogenase (quinone) › A redox-mediated conformational change in NQO1...
questionsmedicales.fr › Métabolisme › Métabolisme énergétique › Oxydoréduction › A redox-mediated conformational change in NQO1...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Sirtuines › Sirtuine-2 › A redox-mediated conformational change in NQO1...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Tubuline › A redox-mediated conformational change in NQO1...