Links between objective sleep and sleep variability measures and inflammatory markers in adults with bipolar disorder.
Interleukin-6
Serious mental illness
Total sleep time
Journal
Journal of psychiatric research
ISSN: 1879-1379
Titre abrégé: J Psychiatr Res
Pays: England
ID NLM: 0376331
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
12
06
2020
revised:
13
10
2020
accepted:
09
12
2020
pubmed:
29
12
2020
medline:
20
5
2021
entrez:
28
12
2020
Statut:
ppublish
Résumé
Premature mortality and increased physical comorbidity associated with bipolar disorder (BD) may be related to accelerated biological aging. Sleep disturbances and inflammation may be key mechanisms underlying accelerated aging in adults with BD. To our knowledge, these relationships have not been examined rigorously. This cross-sectional study included 50 adults with BD and 73 age- and sex-comparable non-psychiatric comparison (NC) subjects, age 26-65 years. Participants were assessed with wrist-worn actigraphy for total sleep time (TST), percent sleep (PS), and bed/wake times for 7 consecutive nights as well as completing scales for subjective sleep quality. Within-individual variability in sleep measures included intra-individual standard deviation (iSD) and atypicality of one evening's sleep. Blood-based inflammatory biomarkers included interleukin (IL)-6, C-reactive protein (CRP), and tumor necrosis factor-alpha (TNF-α). Linear regression analyses tested relationships of mean and iSD sleep variables with inflammatory marker levels; time-lagged analyses tested the influence of the previous evening's sleep on inflammation. BD participants had worse subjective sleep quality, as well as greater TST iSD and wake time iSD compared to the NC group. In all participants, higher TST iSD and lower mean PS were associated with higher IL-6 levels (p = 0.04, η
Identifiants
pubmed: 33360441
pii: S0022-3956(20)31127-4
doi: 10.1016/j.jpsychires.2020.12.019
pmc: PMC7899704
mid: NIHMS1657457
pii:
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
8-14Subventions
Organisme : NIA NIH HHS
ID : K01 AG061239
Pays : United States
Organisme : NHLBI NIH HHS
ID : R21 HL121794
Pays : United States
Organisme : NHLBI NIH HHS
ID : K24 HL132105
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL119201
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL085188
Pays : United States
Organisme : NIMH NIH HHS
ID : K23 MH119375
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH103318
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL134632
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL081823
Pays : United States
Organisme : NIMH NIH HHS
ID : T32 MH019934
Pays : United States
Informations de copyright
Published by Elsevier Ltd.
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