Molecular basis of nucleosomal H3K36 methylation by NSD methyltransferases.
Binding Sites
Biocatalysis
Cell Line, Tumor
Cell Proliferation
Cryoelectron Microscopy
Heterografts
Histone-Lysine N-Methyltransferase
/ genetics
Histones
/ chemistry
Humans
Methylation
Models, Molecular
Multiprotein Complexes
/ chemistry
Mutation
Neoplasm Transplantation
Neoplasms
/ genetics
Nuclear Proteins
/ genetics
Nucleosomes
/ chemistry
Phenotype
Protein Binding
Repressor Proteins
/ genetics
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
17
12
2019
accepted:
27
10
2020
pubmed:
29
12
2020
medline:
20
3
2021
entrez:
28
12
2020
Statut:
ppublish
Résumé
Histone methyltransferases of the nuclear receptor-binding SET domain protein (NSD) family, including NSD1, NSD2 and NSD3, have crucial roles in chromatin regulation and are implicated in oncogenesis
Identifiants
pubmed: 33361816
doi: 10.1038/s41586-020-03069-8
pii: 10.1038/s41586-020-03069-8
pmc: PMC7889650
mid: NIHMS1641450
doi:
Substances chimiques
Histones
0
Multiprotein Complexes
0
Nuclear Proteins
0
Nucleosomes
0
Repressor Proteins
0
Histone-Lysine N-Methyltransferase
EC 2.1.1.43
NSD2 protein, human
EC 2.1.1.43
NSD3 protein, human
EC 2.1.1.43
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
498-503Subventions
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM079641
Pays : United States
Commentaires et corrections
Type : CommentIn
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