A genetic history of the pre-contact Caribbean.


Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
02 2021
Historique:
received: 31 05 2020
accepted: 10 11 2020
pubmed: 29 12 2020
medline: 19 3 2021
entrez: 28 12 2020
Statut: ppublish

Résumé

Humans settled the Caribbean about 6,000 years ago, and ceramic use and intensified agriculture mark a shift from the Archaic to the Ceramic Age at around 2,500 years ago

Identifiants

pubmed: 33361817
doi: 10.1038/s41586-020-03053-2
pii: 10.1038/s41586-020-03053-2
pmc: PMC7864882
mid: NIHMS1645837
doi:

Types de publication

Historical Article Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

103-110

Subventions

Organisme : NIGMS NIH HHS
ID : R01 GM100233
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States

Références

Rouse, I. The Tainos: Rise & Decline of the People who Greeted Columbus (Yale Univ. Press, 1992).
Maggiolo, M. V. La Isla de Santo Domingo antes de Colón (Banco Central de la Republica Dominicana, 1993).
Keegan, W. F. & Hofman, C. L. The Caribbean before Columbus (Oxford Univ. Press, 2017).
Nägele, K. et al. Genomic insights into the early peopling of the Caribbean. Science 369, 456–460 (2020).
pubmed: 32499399
Cook, S. F. & Borah, W. Essays in Population History Vol. 1, 376–410 (Univ. California Press, 1971).
Henige, D. On the contact population of Hispaniola: history as higher mathematics. Hisp. Am. Hist. Rev. 58, 217–237 (1978).
Wilson, S. M. The Archaeology of the Caribbean (Cambridge Univ. Press, 2007).
Rodríguez Ramos, R. in Oxford Handbook of Caribbean Archaeology (eds Keegan, W. F. et al.) 155–170 (Oxford Univ. Press, 2013).
Bérard, B. About boxes and labels: a periodization of the Amerindian occupation of the West Indies. Journal of Caribbean Archaeology 19, 51–67 (2019).
Callaghan, R. T. in Oxford Handbook of Caribbean Archaeology (eds Keegan, W. F. et al.) 285–295 (Oxford Univ. Press, 2013).
Siegel, P. E. et al. Paleoenvironmental evidence for first human colonization of the eastern Caribbean. Quat. Sci. Rev. 129, 275–295 (2015).
Oliver, J. R. The Archaeological, Linguistic and Ethnohistorical Evidence for the Expansion of Arawakan into Northwestern Venezuela and Northeastern Colombia. PhD thesis, Univ. Illinois at Urbana-Champaign (1989).
Reich, D. et al. Reconstructing Native American population history. Nature 488, 370–374 (2012).
pubmed: 22801491 pmcid: 3615710
Eisenmann, S. et al. Reconciling material cultures in archaeology with genetic data: The nomenclature of clusters emerging from archaeogenomic analysis. Sci. Rep. 8, 13003 (2018). 
Greenberg, J. H. Language in the Americas (Stanford Univ. Press, 1987).
Salzano, F. M., Hutz, M. H., Salamoni, S. P., Rohr, P. & Callegari-Jacques, S. M. Genetic support for proposed patterns of relationship among lowland South American languages. Curr. Anthropol. 46, S121–S128 (2005).
Schroeder, H. et al. Origins and genetic legacies of the Caribbean Taino. Proc. Natl Acad. Sci. USA 115, 2341–2346 (2018).
pubmed: 29463742
Pickrell, J. K. & Pritchard, J. K. Inference of population splits and mixtures from genome-wide allele frequency data. PLoS Genet. 8, e1002967 (2012).
pubmed: 23166502 pmcid: 3499260
Chinique de Armas, Y., Roksandic, M., Suárez, R. R., Smith, D. G. & Buhay, W. M. in Cuban Archaeology in the Circum-Caribbean Context (ed. Roksandic, I.) 125–146 (Univ. Press Florida, 2016).
Lovén, S. E. Origins of the Tainan Culture, West Indies (Elanders, 1935).
Nieves-Colón, M. A. et al. Ancient DNA reconstructs the genetic legacies of precontact Puerto Rico communities. Mol. Biol. Evol. 37, 611–626 (2020).
pubmed: 31710665
Moreno-Estrada, A. et al. Reconstructing the population genetic history of the Caribbean. PLoS Genet. 9, e1003925 (2013).
pubmed: 24244192 pmcid: 3828151
Narasimhan, V. M. et al. The formation of human populations in South and Central Asia. Science 365, eaat7487 (2019).
pubmed: 31488661 pmcid: 6822619
Ross, A. H., Keegan, W. F., Pateman, M. P. & Young, C. B. Faces divulge the origins of Caribbean prehistoric inhabitants. Sci. Rep. 10, 147 (2020).
pubmed: 31924849 pmcid: 6954214
Ringbauer, H., Novembre, J. & Steinrucken, M. Human parental relatedness through time - detecting runs of homozygosity in ancient DNA. Preprint at https://doi.org/10.1101/2020.05.31.126912 (2020).
Ceballos, F. C., Joshi, P. K., Clark, D. W., Ramsay, M. & Wilson, J. F. Runs of homozygosity: windows into population history and trait architecture. Nat. Rev. Genet. 19, 220–234 (2018).
Frankham, R. Effective population size/adult population size ratios in wildlife: a review. Genet. Res. 89, 491–503 (2007).
pubmed: 18976539
Browning, S. R. & Browning, B. L. Accurate non-parametric estimation of recent effective population size from segments of identity by descent. Am. J. Hum. Genet. 97, 404–418 (2015).
pubmed: 26299365 pmcid: 4564943
Fortes-Lima, C. et al. Exploring Cuba’s population structure and demographic history using genome-wide data. Sci. Rep. 8, 11422 (2018).
pubmed: 30061702 pmcid: 6065444
Toro-Labrador, G., Wever, O. R. & Martínez-Cruzado, J. C. Mitochondrial DNA analysis in Aruba: strong maternal ancestry of closely related Amerindians and implications for the peopling of northwestern Venezuela. Caribb. J. Sci. 39, 11–22 (2003).
Mendizabal, I. et al. Genetic origin, admixture, and asymmetry in maternal and paternal human lineages in Cuba. BMC Evol. Biol. 8, 213 (2008).
pubmed: 18644108 pmcid: 2492877
Vilar, M. G. et al. Genetic diversity in Puerto Rico and its implications for the peopling of the Island and the West Indies. Am. J. Phys. Anthropol. 155, 352–368 (2014).
pubmed: 25043798
Benn Torres, J. et al. Genetic diversity in the Lesser Antilles and its implications for the settlement of the Caribbean basin. PLoS ONE 10, e0139192 (2015).
pubmed: 26447794 pmcid: 4598113
The 1000 Genomes Project Consortium. A global reference for human genetic variation. Nature 526, 68–74 (2015).
Hofman, C. L. & Reid, B. A. in Encyclopedia of Caribbean Archaeology (eds Reid, B. & Gilmore, G.) 300–303 (Univ. Press Florida, 2014).
Roksandic, I. & Roksandic, M. in New Perspectives on the Peopling of the Americas (eds Harvati, K. et al.) 199–223 (Kerns, 2018).
Keegan, W. The People Who Discovered Columbus (Univ. Press Florida, 1992).
Anderson-Córdova, K. F. Surviving Spanish Conquest: Indian Fight, Flight, and Transformation in Hispaniola and Puerto Rico (Univ. Alabama Press, 2017).
Pinhasi, R. et al. Optimal ancient DNA yields from the inner ear part of the human petrous Bone. PLoS ONE 10, e0129102 (2015).
pubmed: 26086078 pmcid: 4472748
Pinhasi, R., Fernandes, D. M., Sirak, K. & Cheronet, O. Isolating the human cochlea to generate bone powder for ancient DNA analysis. Nat. Protocols 14, 1194–1205 (2019).
pubmed: 30842617
Sirak, K. et al. Human auditory ossicles as an alternative optimal source of ancient DNA. Genome Res. 30, 427–436 (2020).
pubmed: 32098773 pmcid: 7111520
Dabney, J. et al. Complete mitochondrial genome sequence of a Middle Pleistocene cave bear reconstructed from ultrashort DNA fragments. Proc. Natl Acad. Sci. USA 110, 15758–15763 (2013).
pubmed: 24019490
Korlević, P. et al. Reducing microbial and human contamination in DNA extractions from ancient bones and teeth. Biotechniques 59, 87–93 (2015).
pubmed: 26260087
Rohland, N., Glocke, I., Aximu-Petri, A. & Meyer, M. Extraction of highly degraded DNA from ancient bones, teeth and sediments for high-throughput sequencing. Nat. Protocols 13, 2447–2461 (2018).
pubmed: 30323185
Rohland, N., Harney, E., Mallick, S., Nordenfelt, S. & Reich, D. Partial uracil-DNA-glycosylase treatment for screening of ancient DNA. Phil. Trans. R. Soc. Lond. B 370, 20130624 (2015).
Gansauge, M.-T., Aximu-Petri, A., Nagel, S. & Meyer, M. Manual and automated preparation of single-stranded DNA libraries for the sequencing of DNA from ancient biological remains and other sources of highly degraded DNA. Nat. Protocols 15, 2279–2300 (2020).
pubmed: 32612278
Briggs, A. W. et al. Removal of deaminated cytosines and detection of in vivo methylation in ancient DNA. Nucleic Acids Res. 38, e87 (2010).
pubmed: 20028723
Fu, Q. et al. A revised timescale for human evolution based on ancient mitochondrial genomes. Curr. Biol. 23, 553–559 (2013).
pubmed: 23523248 pmcid: 5036973
Fu, Q. et al. An early modern human from Romania with a recent Neanderthal ancestor. Nature 524, 216–219 (2015).
pubmed: 26098372 pmcid: 4537386
Haak, W. et al. Massive migration from the steppe was a source for Indo-European languages in Europe. Nature 522, 207–211 (2015).
pubmed: 25731166 pmcid: 5048219
Mathieson, I. et al. Genome-wide patterns of selection in 230 ancient Eurasians. Nature 528, 499–503 (2015).
pubmed: 26595274 pmcid: 4918750
Behar, D. M. et al. A “Copernican” reassessment of the human mitochondrial DNA tree from its root. Am. J. Hum. Genet. 90, 675–684 (2012).
pubmed: 22482806 pmcid: 3322232
Li, H. & Durbin, R. Fast and accurate long-read alignment with Burrows–Wheeler transform. Bioinformatics 26, 589–595 (2010).
pubmed: 20080505 pmcid: 2828108
Korneliussen, T. S., Albrechtsen, A. & Nielsen, R. ANGSD: analysis of next generation sequencing data. BMC Bioinformatics 15, 356 (2014).
pubmed: 25420514 pmcid: 4248462
Nakatsuka, N. et al. ContamLD: estimation of ancient nuclear DNA contamination using breakdown of linkage disequilibrium. Genome Biol. 21, 199 (2020).
pubmed: 32778142 pmcid: 7418405
Kennett, D. J. et al. Archaeogenomic evidence reveals prehistoric matrilineal dynasty. Nat. Commun. 8, 14115 (2017).
pubmed: 28221340 pmcid: 5321759
Lohse, J. C., Culleton, B. J., Black, S. L. & Kennett, D. J. A precise chronology of Middle to Late Holocene bison exploitation in the far southern Great Plains. J. Texas Arch. Hist. 1, 94–126 (2014).
Bronk Ramsey, C. Bayesian analysis of radiocarbon dates. Radiocarbon 51, 337–360 (2009).
Reimer, P. J. et al. The IntCal20 northern hemisphere radiocarbon age calibration curve (0–55 cal kBP). Radiocarbon 62, 725–757 (2020).
Passariello, I. et al. Characterization of different chemical procedures for
Lindo, J. et al. The genetic prehistory of the Andean highlands 7000 years BP though European contact. Sci. Adv. 4, eaau4921 (2018).
pubmed: 30417096 pmcid: 6224175
Moreno-Mayar, J. V. et al. Early human dispersals within the Americas. Science 362, eaav2621 (2018).
pubmed: 30409807
Scheib, C. L. et al. Ancient human parallel lineages within North America contributed to a coastal expansion. Science 360, 1024–1027 (2018).
pubmed: 29853687
Posth, C. et al. Reconstructing the deep population history of Central and South America. Cell 175, 1185–1197.e22 (2018).
pubmed: 30415837 pmcid: 6327247
Raghavan, M. et al. Genomic evidence for the Pleistocene and recent population history of Native Americans. Science 349, aab3884 (2015).
pubmed: 26198033 pmcid: 4733658
Mallick, S. et al. The Simons Genome Diversity Project: 300 genomes from 142 diverse populations. Nature 538, 201–206 (2016).
pubmed: 27654912 pmcid: 5161557
Patterson, N. et al. Ancient admixture in human history. Genetics 192, 1065–1093 (2012).
pubmed: 22960212 pmcid: 3522152
Lazaridis, I. et al. Ancient human genomes suggest three ancestral populations for present-day Europeans. Nature 513, 409–413 (2014).
pubmed: 25230663 pmcid: 4170574
Skoglund, P. et al. Genetic evidence for two founding populations of the Americas. Nature 525, 104–108 (2015).
pubmed: 26196601 pmcid: 4982469
Olalde, I. et al. The genomic history of the Iberian peninsula over the past 8000 years. Science 363, 1230–1234 (2019).
pubmed: 30872528 pmcid: 6436108
Nakatsuka, N. et al. A paleogenomic reconstruction of the deep population history of the Andes. Cell 181, 1131–1145.e21 (2020).
pubmed: 32386546 pmcid: 7304944
Skoglund, P. et al. Genomic insights into the peopling of the southwest Pacific. Nature 538, 510–513 (2016).
pubmed: 27698418 pmcid: 5515717
Harney, É. et al. Ancient DNA from Chalcolithic Israel reveals the role of population mixture in cultural transformation. Nat. Commun. 9, 3336 (2018).
pubmed: 30127404 pmcid: 6102297
Patterson, N., Price, A. L. & Reich, D. Population structure and eigenanalysis. PLoS Genet. 2, e190 (2006).
pubmed: 17194218 pmcid: 1713260
Alexander, D. H., Novembre, J. & Lange, K. Fast model-based estimation of ancestry in unrelated individuals. Genome Res. 19, 1655–1664 (2009).
pubmed: 19648217 pmcid: 2752134
Alexander, D. H. & Lange, K. Enhancements to the ADMIXTURE algorithm for individual ancestry estimation. BMC Bioinformatics 12, 246 (2011).
pubmed: 21682921 pmcid: 3146885
Chang, C. C. et al. Second-generation PLINK: rising to the challenge of larger and richer datasets. Gigascience 4, 7 (2015).
pubmed: 25722852 pmcid: 4342193
Fu, Q. et al. The genetic history of Ice Age Europe. Nature 534, 200–205 (2016).
pubmed: 27135931 pmcid: 4943878
Lipson, M. Applying f
Harney, É., Patterson, N., Reich, D. & Wakeley, J. Assessing the performance of qpAdm: a statistical tool for studying population admixture. Preprint at https://doi.org/10.1101/2020.04.09.032664 (2020).
Li, H. et al. The Sequence Alignment/Map format and SAMtools. Bioinformatics 25, 2078–2079 (2009).
pubmed: 19505943 pmcid: 2723002

Auteurs

Daniel M Fernandes (DM)

Department of Evolutionary Anthropology, University of Vienna, Vienna, Austria.
CIAS, Department of Life Sciences, University of Coimbra, Coimbra, Portugal.

Kendra A Sirak (KA)

Department of Genetics, Harvard Medical School, Boston, MA, USA.
Department of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA.

Harald Ringbauer (H)

Department of Genetics, Harvard Medical School, Boston, MA, USA.
Department of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA.

Jakob Sedig (J)

Department of Genetics, Harvard Medical School, Boston, MA, USA.
Department of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA.

Nadin Rohland (N)

Department of Genetics, Harvard Medical School, Boston, MA, USA.
Broad Institute of Harvard and MIT, Cambridge, MA, USA.

Olivia Cheronet (O)

Department of Evolutionary Anthropology, University of Vienna, Vienna, Austria.

Matthew Mah (M)

Department of Genetics, Harvard Medical School, Boston, MA, USA.
Department of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA.
Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA.

Swapan Mallick (S)

Department of Genetics, Harvard Medical School, Boston, MA, USA.
Department of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA.
Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA.

Iñigo Olalde (I)

Department of Genetics, Harvard Medical School, Boston, MA, USA.
Institute of Evolutionary Biology, CSIC-Universitat Pompeu Fabra, Barcelona, Spain.

Brendan J Culleton (BJ)

Institutes of Energy and the Environment, The Pennsylvania State University, University Park, PA, USA.

Nicole Adamski (N)

Department of Genetics, Harvard Medical School, Boston, MA, USA.
Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA.

Rebecca Bernardos (R)

Department of Genetics, Harvard Medical School, Boston, MA, USA.
Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA.

Guillermo Bravo (G)

Department of Evolutionary Anthropology, University of Vienna, Vienna, Austria.
Department of Legal Medicine, Toxicology and Physical Anthropology, University of Granada, Granada, Spain.

Nasreen Broomandkhoshbacht (N)

Department of Genetics, Harvard Medical School, Boston, MA, USA.
Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA.
Department of Anthropology, University of California, Santa Cruz, CA, USA.

Kimberly Callan (K)

Department of Genetics, Harvard Medical School, Boston, MA, USA.
Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA.

Francesca Candilio (F)

Superintendency of Archaeology, Fine Arts and Landscape for the city of Cagliari and the provinces of Oristano and South Sardinia, Cagliari, Italy.

Lea Demetz (L)

Department of Evolutionary Anthropology, University of Vienna, Vienna, Austria.

Kellie Sara Duffett Carlson (KSD)

Department of Evolutionary Anthropology, University of Vienna, Vienna, Austria.

Laurie Eccles (L)

Department of Anthropology, The Pennsylvania State University, University Park, PA, USA.

Suzanne Freilich (S)

Department of Evolutionary Anthropology, University of Vienna, Vienna, Austria.

Richard J George (RJ)

Department of Anthropology, University of California, Santa Barbara, CA, USA.

Ann Marie Lawson (AM)

Department of Genetics, Harvard Medical School, Boston, MA, USA.
Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA.

Kirsten Mandl (K)

Department of Evolutionary Anthropology, University of Vienna, Vienna, Austria.

Fabio Marzaioli (F)

Department of Mathematics and Physics, Campania University 'Luigi Vanvitelli', Caserta, Italy.

Weston C McCool (WC)

Department of Anthropology, University of California, Santa Barbara, CA, USA.

Jonas Oppenheimer (J)

Department of Genetics, Harvard Medical School, Boston, MA, USA.
Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA.
Department of Biomolecular Engineering, University of California, Santa Cruz, CA, USA.

Kadir T Özdogan (KT)

Department of Evolutionary Anthropology, University of Vienna, Vienna, Austria.

Constanze Schattke (C)

Department of Evolutionary Anthropology, University of Vienna, Vienna, Austria.

Ryan Schmidt (R)

CIBIO-InBIO, University of Porto, Vairão, Portugal.

Kristin Stewardson (K)

Department of Genetics, Harvard Medical School, Boston, MA, USA.
Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA.

Filippo Terrasi (F)

Department of Mathematics and Physics, Campania University 'Luigi Vanvitelli', Caserta, Italy.

Fatma Zalzala (F)

Department of Genetics, Harvard Medical School, Boston, MA, USA.
Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA.

Carlos Arredondo Antúnez (CA)

Museo Antropológico Montané, University of Havana, Havana, Cuba.

Ercilio Vento Canosa (EV)

Matanzas University of Medical Sciences, Matanzas, Cuba.

Roger Colten (R)

Peabody Museum of Natural History, Yale University, New Haven, CT, USA.

Andrea Cucina (A)

Facultad de Ciencias Antropológicas, Universidad Autónoma de Yucatán, Mérida, Mexico.

Francesco Genchi (F)

Department of Environmental Biology, Sapienza University of Rome, Rome, Italy.

Claudia Kraan (C)

National Archaeological-Anthropological Memory Management (NAAM), Willemstad, Curaçao.

Francesco La Pastina (F)

Department of Environmental Biology, Sapienza University of Rome, Rome, Italy.

Michaela Lucci (M)

DANTE Laboratory of Diet and Ancient Technology, Sapienza University of Rome, Rome, Italy.

Marcio Veloz Maggiolo (MV)

Universidad Autónoma de Santo Domingo, San Francisco de Macorís, Dominican Republic.

Beatriz Marcheco-Teruel (B)

National Center of Medical Genetics, Medical University of Havana, Havana, Cuba.

Clenis Tavarez Maria (CT)

Museo del Hombre Dominicano, Santo Domingo, Dominican Republic.

Christian Martínez (C)

Museo del Hombre Dominicano, Santo Domingo, Dominican Republic.

Ingeborg París (I)

Instituto de Investigaciones Bioantropológicas y Arqueológicas, Universidad de Los Andes, Mérida, Venezuela.

Michael Pateman (M)

Turks and Caicos National Museum Foundation, Cockburn Town, Turks and Caicos Islands.
AEX Bahamas Maritime Museum, Freeport, Bahamas.

Tanya M Simms (TM)

Department of Biology, University of The Bahamas, Nassau, Bahamas.

Carlos Garcia Sivoli (CG)

Instituto de Investigaciones Bioantropológicas y Arqueológicas, Universidad de Los Andes, Mérida, Venezuela.

Miguel Vilar (M)

National Geographic Society, Washington, DC, USA.

Douglas J Kennett (DJ)

Department of Anthropology, University of California, Santa Barbara, CA, USA.

William F Keegan (WF)

Florida Museum of Natural History, University of Florida, Gainesville, FL, USA.

Alfredo Coppa (A)

Department of Evolutionary Anthropology, University of Vienna, Vienna, Austria. alfredo.coppa@uniroma1.it.
Department of Genetics, Harvard Medical School, Boston, MA, USA. alfredo.coppa@uniroma1.it.
Department of Environmental Biology, Sapienza University of Rome, Rome, Italy. alfredo.coppa@uniroma1.it.

Mark Lipson (M)

Department of Genetics, Harvard Medical School, Boston, MA, USA.
Department of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA.

Ron Pinhasi (R)

Department of Evolutionary Anthropology, University of Vienna, Vienna, Austria. ron.pinhasi@univie.ac.at.

David Reich (D)

Department of Genetics, Harvard Medical School, Boston, MA, USA. reich@genetics.med.harvard.edu.
Department of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA. reich@genetics.med.harvard.edu.
Broad Institute of Harvard and MIT, Cambridge, MA, USA. reich@genetics.med.harvard.edu.
Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA. reich@genetics.med.harvard.edu.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female
Humans United States Aged Cross-Sectional Studies Medicare Part C
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH