Thymosin alpha 1: A comprehensive review of the literature.
Immune deficiency
Immunomodulating
Infectious diseases
Oxidative damage
T lymphocytes
Thymalfasin
Thymosin alpha 1
Journal
World journal of virology
ISSN: 2220-3249
Titre abrégé: World J Virol
Pays: United States
ID NLM: 101608353
Informations de publication
Date de publication:
15 Dec 2020
15 Dec 2020
Historique:
received:
13
10
2020
revised:
19
11
2020
accepted:
02
12
2020
entrez:
28
12
2020
pubmed:
29
12
2020
medline:
29
12
2020
Statut:
ppublish
Résumé
Thymosin alpha 1 is a peptide naturally occurring in the thymus that has long been recognized for modifying, enhancing, and restoring immune function. Thymosin alpha 1 has been utilized in the treatment of immunocompromised states and malignancies, as an enhancer of vaccine response, and as a means of curbing morbidity and mortality in sepsis and numerous infections. Studies have postulated that thymosin alpha 1 could help improve the outcome in severely ill corona virus disease 2019 patients by repairing damage caused by overactivation of lymphocytic immunity and how thymosin alpha 1 could prevent the excessive activation of T cells. In this review, we discuss key literature on the background knowledge and current clinical uses of thymosin alpha 1. Considering the known biochemical properties including antibacterial and antiviral properties, time-honored applications, and the new promising findings regarding the use of thymosin, we believe that thymosin alpha 1 deserves further investigation into its antiviral properties and possible repurposing as a treatment against severe acute respiratory syndrome coronavirus-2.
Identifiants
pubmed: 33362999
doi: 10.5501/wjv.v9.i5.67
pmc: PMC7747025
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
67-78Informations de copyright
©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Déclaration de conflit d'intérêts
Conflict-of-interest statement: Authors declare no conflict of interests for this article.
Références
Vitam Horm. 2016;102:25-54
pubmed: 27450729
Vitam Horm. 2016;102:151-78
pubmed: 27450734
J Gastroenterol Hepatol. 2004 Dec;19 Suppl 6:S79-81
pubmed: 15546256
Biotechnol Appl Biochem. 2009 Apr;52(Pt 4):303-12
pubmed: 18752465
Lymphokine Res. 1989 Winter;8(4):383-91
pubmed: 2572736
Blood. 2004 Jun 1;103(11):4232-9
pubmed: 14982877
Am J Health Syst Pharm. 2001 May 15;58(10):879-85; quiz 886-8
pubmed: 11381492
Crit Care. 2013 Jan 17;17(1):R8
pubmed: 23327199
Chem Biol Interact. 2009 Aug 14;180(3):383-8
pubmed: 19442654
Clin Biochem. 2005 Jun;38(6):540-7
pubmed: 15885234
Ann N Y Acad Sci. 2010 Apr;1194:130-5
pubmed: 20536460
Apoptosis. 2015 Aug;20(8):1109-21
pubmed: 26002438
Hepatol Res. 2002 Dec;24(4):346-354
pubmed: 12479932
Ann N Y Acad Sci. 2010 Apr;1194:136-40
pubmed: 20536461
Int J Infect Dis. 2015 Apr;33:90-6
pubmed: 25532482
J Prev Med Hyg. 2011 Sep;52(3):111-5
pubmed: 22010537
Front Oncol. 2019 Sep 06;9:873
pubmed: 31555601
Biocell. 2005 Dec;29(3):253-9
pubmed: 16524246
Peptides. 2010 Nov;31(11):2151-8
pubmed: 20699109
Clin Lymphoma Myeloma Leuk. 2020 Jul;20(7):e352-e367
pubmed: 32249195
Future Microbiol. 2017 Feb;12:141-155
pubmed: 28106477
Vitam Horm. 2016;102:121-49
pubmed: 27450733
Cell Death Discov. 2020 Jun 12;6:49
pubmed: 32547788
Data Brief. 2017 Nov 07;16:135-140
pubmed: 29201980
Vaccine. 2012 Feb 1;30(6):1170-80
pubmed: 22178096
Immunotherapy. 2012 Jan;4(1):107-20
pubmed: 22150004
Cell Res. 2020 Sep;30(9):814-816
pubmed: 32759967
Biochem Biophys Res Commun. 2011 Dec 16;416(3-4):356-61
pubmed: 22115779
Ann N Y Acad Sci. 2007 Sep;1112:235-44
pubmed: 17567942
Vitam Horm. 2016;102:1-24
pubmed: 27450728
Ann N Y Acad Sci. 2007 Sep;1112:326-38
pubmed: 17495242
Int J Immunopharmacol. 1994 Dec;16(12):1019-25
pubmed: 7705963
Expert Opin Biol Ther. 2018 Jul;18(sup1):13-21
pubmed: 30063864
Expert Opin Biol Ther. 2015;15 Suppl 1:S117-27
pubmed: 26098768
Ann N Y Acad Sci. 2007 Sep;1112:297-304
pubmed: 17567944
Vitam Horm. 2016;102:55-71
pubmed: 27450730
Hepatology. 1998 May;27(5):1383-7
pubmed: 9581695
AAPS PharmSciTech. 2000 May 14;1(2):E11
pubmed: 14727844
Ann N Y Acad Sci. 2012 Oct;1270:21-7
pubmed: 23050813
Emerg Microbes Infect. 2020 Dec;9(1):1230-1232
pubmed: 32515651
J Med Virol. 2020 May;92(5):479-490
pubmed: 32052466