Neutrophils as Orchestrators in Tumor Development and Metastasis Formation.
cancer-dependent granulopoiesis
immune modulation
innate immune memory
metastasis
neutrophil
trained granulopoiesis
trained immunity
tumor
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2020
2020
Historique:
received:
08
07
2020
accepted:
10
11
2020
entrez:
28
12
2020
pubmed:
29
12
2020
medline:
29
12
2020
Statut:
epublish
Résumé
Several lines of clinical and experimental evidence suggest that immune cell plasticity is a central player in tumorigenesis, tumor progression, and metastasis formation. Neutrophils are able to promote or inhibit tumor growth. Through their interaction with tumor cells or their crosstalk with other immune cell subsets in the tumor microenvironment, they modulate tumor cell survival. Here, we summarize current knowledge with regards to the mechanisms that underlie neutrophil-mediated effects on tumor establishment and metastasis development. We also discuss the tumor-mediated effects on granulopoiesis and neutrophil precursors in the bone marrow and the involvement of neutrophils in anti-tumor therapeutic modalities.
Identifiants
pubmed: 33363012
doi: 10.3389/fonc.2020.581457
pmc: PMC7758500
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
581457Informations de copyright
Copyright © 2020 Kalafati, Mitroulis, Verginis, Chavakis and Kourtzelis.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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